Phytoconstituents of two L. species and cytotoxic activity of the isolated curcumin analogues.

Methanolic extracts of L. fruits and Desf. leaves yielded two mono-carbonyl curcumin analogues; (1,4)-1,5-(4-hydroxy-3-methoxyphenyl)penta-1,4-dien-3-one [], (1,4)-1,5-(4-hydroxyphenyl)penta-1,4-dien-3-one [], in addition to -sitosterol [], apigenin [], quercetin-3`--methyl ether [], rutin [], quercetin [], naringenin [], eriodictyol [], vitexin [], isovitexin [], gleditsin A [].

Identifying cancer-related molecular targets of Nandina domestica Thunb. by network pharmacology-based analysis in combination with chemical profiling and molecular docking studies.

Ethnopharmacological Relevance: The fruits of Nandina domestica Thunb. have served as folk medicines in Chinese and Japanese tradition for treatment of several tumors including pharynx tumor and tooth abscess for many years, yet its exact mechanism of action is not yet known.

Aim Of The Study: The study targets the identification of the main constituents of the fruits extracts and investigation of their mode of action in cancer therapy via pharmacology-based analysis and molecular docking.