Publications by authors named "Marwa Lakhrem"
Article Synopsis
- Lancehead snakes (Bothrops) cause 90% of snakebites in Latin America, prompting a study on the effects of B. atrox venom in male and female mice.
- The research found that male mice exhibited a lower lethal dose (LD) and more severe physical symptoms from the venom compared to females, particularly via the intraperitoneal injection route.
- Hematological changes, including a significant drop in total leukocyte levels, were more pronounced in males, indicating a greater susceptibility to B. atrox venom and highlighting the need to consider sex differences in venom studies.
The purpose of this paper was to investigate the anti-inflammatory and anti-angiogenic activities of sulfated polysaccharide from (PCT) using carrageenan (CARR)-induced paw edema in a rat model and anti-vasculogenic activity on a chorioallantoic membrane assay (CAM) model. Based on in vitro tests of anti-radical, total antioxidant, and reducing power activities, PCT presents a real interest via its antioxidant activity and ability to scavenge radical species. The in vivo pharmacological tests suggest that PCT possesses anti-inflammatory action by reducing paw edema and leukocyte migration, maintaining the redox equilibrium, and stabilizing the cellular level of several pro-/antioxidant system markers.
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