Influence of alendronate administration regimen on the final outcome of implant osseointegration in an osteoporotic model.

This study aimed to evaluate the bone response around titanium implants in osteoporotic rabbits receiving oral alendronate (ALN) for one month either simultaneously with implant placement (IP) or stopped immediately before surgery. Six weeks before IP, 34 adult female New Zealand white rabbits were submitted to intramuscular injections of dexamethasone (3 mg/kg twice a week) to induce osteoporosis-like conditions. Two animals were sacrificed and histological examinations of their leg bones were performed to confirm the osteoporosis-like condition, as compared to a healthy animal.