Publications by authors named "Marwa A Bebars"
Background: Given the sparse data on the renin-angiotensin system (RAS) and its biological effector molecules ACE1 and ACE2 in pediatric COVID-19 cases, we investigated whether the ACE1 insertion/deletion (I/D) polymorphism could be a genetic marker for susceptibility to COVID-19 in Egyptian children and adolescents.
Methods: This was a case-control study included four hundred sixty patients diagnosed with COVID-19, and 460 well-matched healthy control children and adolescents. The I/D polymorphism (rs1799752) in the ACE1 gene was genotyped by polymerase chain reaction (PCR), meanwhile the ACE serum concentrations were assessed by ELISA.
Objective: This is a comprehensive characteristic study of Kawasaki disease (KD) and Multi system inflammatory syndrome in children (MIS-C) in the Middle East that creates a formula to differentiate between the two.
Methods: We conducted a descriptive comparative study of KD and MIS-C in the United Arab Emirates. Retrospective MIS-C and KD cohorts were recruited between January 2017 until August 2021.
Article Synopsis
- Previous research shows that tumor processes like angiogenesis and metastasis are influenced by the blood coagulation system, particularly tissue factor (TF), which also affects cell signaling related to cancer progression.
- In a study involving 40 neuroblastoma tissue samples, 75% showed positive TF expression, with a significant correlation between TF levels and the MYCN gene's upregulation, indicating a potential link between these factors.
- TF expression was found to be a significant predictor of patient outcomes, with 60% of patients with positive TF expression dying from the disease, suggesting that TF might be a valuable prognostic marker and a target for future treatments in neuroblastoma.