Molecular Basis of Rhodomyrtone Resistance in Staphylococcus aureus.

Rhodomyrtone (Rom) is a plant-derived broad-spectrum antibiotic active against many Gram-positive pathogens. A single point mutation in the regulatory gene (*) confers resistance to Rom in Staphylococcus aureus (RomR). The mutation in * alters the activity of the regulator, FarR*, in such a way that not only its own gene, *, but also the divergently transcribed gene and genes controlled by the global regulator, , are highly upregulated.