Publications by authors named "Marvin Mergen"

Background: In medical education, new technologies like Virtual Reality (VR) are increasingly integrated to enhance digital learning. Originally used to train surgical procedures, now use cases also cover emergency scenarios and non-technical skills like clinical decision-making. This scoping review aims to provide an overview of VR in medical education, including requirements, advantages, disadvantages, as well as evaluation methods and respective study results to establish a foundation for future VR integration into medical curricula.

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Objective: This study aimed to identify parameters that allow the estimation of tumor-infiltrated lymph nodes (LN) after pretreatment for unilateral Wilms tumor (WT).

Summary Background Data: Complete tumor resection with removal of regional LN is always necessary. Positive LNs require local irradiation influencing benefits in case of NSS in long-term follow-up.

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Introduction: Wilms tumor (WT) is the most common childhood kidney cancer. It is a rapid growing embryonal tumor in young children and can be diagnosed with and without tumor related symptoms.

Methods: We retrospectively analyzed the route to diagnosis of WT treated prospectively according to the SIOP 93-01/GPOH and 2001/GPOH in Germany between 1993 and 2022.

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Background: Artificial intelligence (AI) is becoming increasingly important in healthcare. It is therefore crucial that today's medical students have certain basic AI skills that enable them to use AI applications successfully. These basic skills are often referred to as "AI literacy".

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Article Synopsis
  • It's really important to tell different types of kidney tumors apart in kids because treatments start without needing a tissue sample.
  • Researchers looked at details like age, tumor size, and whether tumors had spread in over 3000 kids with different kidney tumors to improve how doctors identify them.
  • They found that different tumors appeared in kids at different ages and sizes, and two specific types (MRTK and RCC) were linked to a higher chance of spreading, showing that understanding these details can help doctors treat kids better!
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Despite excellent outcomes, many open questions remain about Wilms tumor (WT). Influences and risk factors for tumorigenesis, as well as tumor aggressiveness and recurrence, are not fully understood. Parental age plays a role in various childhood diseases and is also discussed as a risk factor for childhood cancer.

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Article Synopsis
  • - The text discusses the necessity for medical students to have effective training for clinical decision-making, which is being increasingly supported by digital methods, particularly through virtual reality (VR) and artificial intelligence (AI) technologies, that allow safe, realistic practice scenarios.
  • - The project aims to create a modular digital training platform called medical tr.AI.ning, which will integrate interactive virtual agents into the medical curriculum to simulate various clinical situations with realistic pathologies and customizable contexts.
  • - To enhance user experience and ensure the training's effectiveness, the authors plan to conduct regular evaluations and iteratively refine the platform, aiming for long-term improvements and insights on the advantages and challenges of this educational approach.
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Background: Due to an increasing focus of medical curricula on clinical decision-making skills, new learning tools are constantly developed. Virtual reality (VR) is one of the emerging technologies with the potential to improve health professionals' education. Highly realistic learning experiences with repeatable training scenarios can be created within a protected environment that is independent from real patients' presence.

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(1) Background: Wilms tumor (WT) treated preoperatively is cured in over 90% of cases. However, how long preoperative chemotherapy can be given is unknown. (2) Methods: 2561/3030 patients with WT (age < 18 years) treated between 1989 and 2022 according to SIOP-9/GPOH, SIOP-93-01/GPOH, and SIOP-2001/GPOH are retrospectively analyzed to assess the risk of time to surgery (TTS) for relapse-free survival (RFS) and overall survival (OS).

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Due to high survival rates, long-term sequelae, especially neurotoxicity, need to be considered in childhood acute leukemias. In this retrospective analysis of morphologic changes of the brain in children treated for acute leukemias, we included 94 patients (77 ALL, 17 AML; 51 male, 43 female; median age: 5 years) from a single center. We analyzed 170 cranial MRI scans (T2, FLAIR axial) for morphologic alterations of the brain and variations of the ventricular width (GDAH).

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