Publications by authors named "Marvin Mazzardo"
Cell Biol Toxicol
February 2023
Article Synopsis
- PARP1 is a key sensor for cellular damage, specifically DNA strand breaks, which helps in DNA repair by recruiting XRCC1 and forming repair complexes.
- The study shows that the recruitment of PARP1 and XRCC1 to DNA damage sites is mutually dependent, emphasizing their collaboration in responding to genotoxic stress.
- Experiments using various cell types revealed that XRCC1 KO cells are more sensitive to certain DNA-damaging treatments, and this sensitivity can be mitigated by further genetic modifications or pharmacological interventions targeting PARP1.
