Vibrational markers of structural distortion in adenine nucleobases upon DNA damage.

Oxidation is one of the common causes of chemical damage of DNA. Among the oxidized nucleobases in DNA, 8-oxoadenine (8-oxoA) and 4,6-diamino-5-formamidoadenine (FaPyA) are two of the most commonly found lesions. Relatively little information has been published so far on these lesions compared to the more mutagenic modified purines like 8-oxoguanine.