Manifestation of the FLASH effect in proton irradiation of embryos.

Purpose: In order to study the FLASH effect using live models, this work compared proton-induced damage to embryos (nine days after fertilization) and one-day-old chicks (18 days after fertilization) from irradiated at different dose rates eggs of Japanese quail ().

Materials And Methods: Eggs were irradiated with protons in different modes depending on the dose rate: in a conventional mode (<1 Gy/s, CONV), in a flash mode (∼100 Gy/s, FLASH) and in a single-pulse flash mode (∼10 Gy/s SPLASH).

Results: By the criteria of body weight and length, as well as the number of erythrocytes with micronuclei in nine-day-old embryos from eggs irradiated in the spread-out Bragg peak (SOBP) (8.

Expression of Genes Related to Meat Productivity, Metabolic and Morphological Significance of Broiler Chickens with the Use of Nutritional Phytochemicals.

The study aimed to analyze gene expression linked to skeletal muscle growth and lipid metabolism in broiler chickens fed with plant extracts. Five groups of chickens were formed: four experimental groups and one control group. The diets of the experimental groups were supplemented with different plant extracts: chicory, St.

Experience in multicatheter interstitial high-dose-rate breast brachytherapy: dose-volume histogram analysis of the first results.

Purpose: To report characteristics of our treatment scheme of high-dose-rate (HDR) brachytherapy of breast cancer and to show the first outcomes of dosimetric planning analysis based on dose-volume histogram (DVH).

Material And Methods: Since August 2017, 25 patients diagnosed with T1N0M0 breast cancer have received a treatment in our center. There was lumpectomy and following breast HDR brachytherapy (10 fractions of 3.

Slow-wave sleep and androgens: selective slow-wave sleep suppression affects testosterone and 17α-hydroxyprogesterone secretion.

Objectives: Levels of steroid hormones such as androgens and cortisol exhibit circadian variation, and their fluctuations are related to the sleep-wake cycle. Currently, the functional role of different stages of sleep in steroid hormone secretion remains unclear. The present study aims to explore the effect of slow-wave sleep (SWS) suppression on morning levels of cortisol and androgens.

[Early physical rehabilitation after elective percutaneous coronary interventions during incomplete revascularization: exercise regimen calculation by ergospirometry].

Aim: To evaluate the efficiency and safety of outpatient physical exercises (PE), calculated using ergospirometry (ESM) in patients in the early periods after elective percutaneous coronary interventions (PCI) during incomplete coronary bed revascularization.

Subjects And Methods: Three hundred and eighty-three patients were screened. The trial enrolled the patients after elective PCI in its early periods (3 to 14 days) who had signed an informed consent document to participate in the investigation and who could perform themselves PE at home or visit the medical center.

[Apoptosis of host cells regulation by Chlamydia].

In a study on the impact of chlamydial infection on host cell apoptosis, C. trachomatis were shown to protect host cell against staurosporin-induced apoptosis only at the middle stage of infection development (at 20 hours post infection), C. pneumoniae--at different stages of its growth cycle (from 2 to 7 day post infection).

[The apoptosis-supressing activity of clamydia].

The paper covers data from literature, concerning the influence of bacteria upon apoptosis program of host's cells. The mechanisms of apoptosis induction and suppression, developed by bacteria and directed towards the maintenance of conditions favorable to the infection, are quite varied. These mechanisms are realized via complex interaction between biologically active bacterial molecules and particular targets of signal paths which lead to apoptosis.

[Role of Chlamydia, mycoplasma and cytomegalovirus infection in the development of coronary artery disease].

Aim: To assess relationship between some infection factors and presence of coronary heart disease.

Material: Patients with myocardial infarction (n=56), unstable angina (n=50), stable angina (n=50) and age - matched controls (n=49).

Methods: Levels of IgG, IgM, IgA antibodies to Chlamydia pneumonia, Chlamydia trachomatis, Chlamydia psittaci, IgG, IgM antibodies to Cytomegalovirus, and also of antibodies and antigen to Mycoplasma pneumoniae were measured in blood serum.

[Role of Chlamydia pneumoniae in the etiology of atherosclerosis].

The review of literature on the role of C. pneumoniae in the etiology of atherosclerosis is presented. The patients with coronary disease show a greater detection rate and higher titers of antibodies to C.

[Investigation of oxosubstances in plant leaf lipids].

Surface lipids of plant leaves of different groups were investigated by spectral, chromatographic and functional analysis methods. Absence of oxosubstances in surface lipids of coniferous and their characteristics in tropical species were shown. Functions of oxosubstances are discussed.

[Pathogenetic aspects of chlamydia-associated urogenic arthritis: feasibility of microorganism reproduction in cells of articular cartilage].

Aim: The study of feasibility of Chlamydia trachomatis infection and reproduction. This microorganism is an essential etiologic factor in urogenic arthritis, in chondrocytes and fibroblasts of human skin.

Materials And Methods: Infection of human skin chondrocytes and fibroblasts was made with chlamydia CP-1 strain isolated from joint fluid of the patient and serially passaged in the hen's embryo yolksacs.

[The use of Cordanum in combination with Corinfar-Retard for the treatment of ectopic arrhythmias in the sick sinus syndrome in patients with ischemic heart disease].

38 patients with ischemic heart disease (IHD) and sick sinus syndrome (SSS) received combined therapy with nifedipine (Corinfar-Retard) and talinolol (Cordanum). The former drug had a positive chronotropic effect on the heart, the latter's chronotropic effect was slightly negative. All the patients had sinus bradycardia and ectopic arrhythmia which needed therapeutic correction: supraventricular and ventricular extrasystoles, fibrillation paroxysms or/and atrial flutter, paroxysmal supraventricular tachycardia, ventricular tachycardia.

[Cytomegalovirus infection in women of reproductive age with an at-risk obstetrical history].

Studies aimed at the detection of cytomegalovirus infection (CMVI) in women of reproductive age with obstetric complications in their medical history were carried out. 230 women aged 17-44 years were examined with the use of virological and serological tests. As the result of complex examination, CMVI markers were detected in 159 (69%) of women.

[Effect of oxygen aeroions on hemostasis and development of arteriosclerosis in hypodynamia].

Experiments on 50 rabbits examined the hemostatic effects of negative oxygen aeroions (AI). In control experiments, keeping the animals under hypodynamia led to 40% animal death, significant aortic atherosclerosis and myocardial infarction. The animals developed the thrombohemorrhagic syndrome with hypercoagulemia and drastically suppressed blood fibrinolytic activity.

[Preparation of monoclonal antibodies to super early human cytomegalovirus proteins and their use for detecting infected cells].

Twenty-six mouse hybridomas producing monoclonal antibodies (MAB) to human cytomegalovirus (CMV) proteins have been obtained. MAB produced by three hybridomas were studied in detail. MAB were active in indirect immunofluorescence and solid-phase enzyme immunoassay, being directed to the super-early viral protein p72.

[The seasonal dynamics of hemostasis and fibrinolysis in the central belt of Russia].

Upon evaluating seasonal shifts in hemostasis in healthy subjects (3200 examinees aged 18-40) it was established that coagulation rate is the highest in spring. This phenomenon occurred in association with activated fibrinolysis, reduced levels of antithrombin III and more marked paracoagulant tests. Natural lysis of the clot and euglobin fibrinolysis proved more intensive in spring, while least intensive in winter.

[The bacteriologic background and an analysis of the resistance of the agent to antibacterial preparations in patients in the postresuscitation period].

A total of 6848 bacteriological passages have been performed in 57 patients during postresuscitation period under bacteriological monitoring that included the investigation of different body media twice daily. A microbial pattern has been compiled, typical of a certain intensive care unit, which served the basis for analysis of the resistance of the most widespread agents of pyoseptic complications to antibacterial preparations, with due consideration for the process site. The scheme of antibacterial therapy suggested made it possible to reduce the incidence of those complications due to the increased efficacy of antibacterial therapy in the postresuscitation period.

[The diagnostic problems in cytomegalovirus infection in patients with a transplanted kidney].

Several methods of cytomegaloviral (CMV) infection diagnosis were studied in patients with a transplanted kidney. EIA was used to examine clinically normal subjects and patients with CMV infection symptoms for the presence of anti-CMV IgM and IgG. Pulmonary cells of the human embryo were infected with the patients' blood and urine, followed by examination for the presence of antigen.