Reductive stress and cytotoxicity in the swollen river mussel (Unio tumidus) exposed to microplastics and salinomycin.

Multistress effects lead to unpredicted consequences in aquatic ecotoxicology and are extremely concerning. The goal of this study was to trace how specific effects of the antibiotic salinomycin (Sal) and microplastics (MP) on the bivalve molluscs are manifested in the combined environmentally relevant exposures. Unio tumidus specimens were treated with Sal (0.

Chlorpromazine's impact on Mytilus galloprovincialis: a multi-faceted investigation.

The antipsychotic chlorpromazine (Cpz) has raised concern as a pharmaceutical effluent due to its wide medical applications. Moreover, its potent pro-oxidant properties and impact on the cell viability of the marine mollusc Mytilus galloprovincialis, even at low concentrations (ng/L), have been noted. Based on this evidence, in this study, we investigated the physiological effects of Cpz on M.

Biochemical basis of resistance to multiple contaminations in the native and invasive populations of Dreissena polymorpha.

The zebra mussel Dreissena polymorpha (Pallas, 1771) is an invasive species and a valuable bioindicator in the inland waters. Nevertheless, the biochemical reasons for the unique competitiveness of zebra mussels are not clear. This study aimed to compare the native and invasive populations of D.

Cellular and oxidative stress responses of to chlorpromazine: implications of an antipsychotic drug exposure study.

Bivalve molluscs like are valuable bioindicators due to their filter-feeding lifestyle, wide distribution, and ability to concentrate xenobiotics. Studying the effects of pharmaceuticals on these molluscs is crucial given their presence in surface waters. This study investigated the response of to chlorpromazine (Cpz), an antipsychotic with antiviral activity against influenza, HIV, and coronaviruses in human cells.

Physiological and biochemical responses to caffeine and microplastics in Mytilus galloprovincialis.

Caffeine (Caff) is one of the most widely used substances in the human diet and a well-recognized drug. Its input into surface waters is remarkable, but biological effects on aquatic organisms are unclear, particularly in combination with pollutants of suspected modulatory activity, like microplastics (MP). The aim of this study was to reveal the impact on the marine mussel Mytilus galloprovincialis (Lamark, 1819) of Caff (20.

Combined effect of microplastic, salinomycin and heating on Unio tumidus.

Microplastic (MP) and heating (T) suspected to modulate biological effects of aquatic contaminants. Salinomycin (Sal) is veterinary antibiotic and anticancer agent. The goal of this study was to examine the multistress effect of MP, Sal and T on the bioindicator bivalve mollusc.

Stress responses of bivalve mollusc Unio tumidus from two areas to ibuprofen, microplastic and their mixture.

Even though bivalve molluscs are recognized as bioindicators of freshwater quality, their responses to multiple stressors are unpredictable. This study aims to elucidate the inter-population peculiarities of the effect in the sub-chronic environmentally relevant exposure to novel contaminants. The specimens of Unio tumidus from reference (Pr) and contaminated (Ct) areas were treated with ibuprofen (IBU, 0.

Indication of the impact of environmental stress on the responses of the bivalve mollusk Unio tumidus to ibuprofen and microplastics based on biomarkers of reductive stress and apoptosis.

The vulnerability of bivalve mollusks to micropollutants is estimated mainly in single model exposures. However, chronic environmental stress and complex exposures can modulate their responses. To evaluate the impact of population-dependent adaptations on the ability to react to common micropollutants, we compared freshwater bivalves Unio tumidus from two distinct populations, pure (Pr) and contaminated (Ct), in their exposures to microplastics (MP, 1 mg L, size 0.

RELATIONSHIP BETWEEN PATHOLOGICAL MENSTRUAL SYMPTOMS AND THE DEVELOPMENT OF EXTRAGENITAL FORMS OF LOCAL INFLAMMATION.

Objective: The aim: To evaluate the parameters of menstrual function in 1015 women of reproductive age and to establish the relationship between the detected menstrual disorders and the development of migraine and/or irritable bowel syndrome (IBS).

Patients And Methods: Materials and methods: During 2018-2020, a survey of women of reproductive age in the Ternopil region (Ukraine) was conducted. To interview the study respondents, we developed a questionnaire that assessed the parameters of menstrual function (age of menarche; regularity and cyclicity of menstrual changes; duration of the menstrual cycle and menstruation itself; the amount of blood loss with the pictogram, the presence of clots and their size) identify characteristic changes in health, symptoms of irritable bowel syndrome and migraine associated with the menstrual cycle.

[Actomyosin ATPase activity of skeletal muscles and the markers of tissue damage in the blood of rats under prolonged chronic alcoholization].

The activity of creatine kinase and indices of lipid metabolism in the blood and also actomyosin ATPase activity of skeletal muscles of rats under chronic 8-month alcohol abuse were investigated. It is shown that actomyosin K+-ATPase activity of skeletal muscles increases from two months of ethanol use, but actomyosin Mg2+-ATPase activity decreases during 6-8 months of alcoholization. From two months of ethanol use the creatine kinase activity, as an enzyme marker of muscle tissue damage, statistically significantly increases during all the period of the animals alcoholization.

[Application of electrowelding technologies in videothoracoscopic pulmonary surgery].

Experience of videothoracoscopic pulmonary resection, using nonsuture electrowelding technology in 42 patients, was summarized. Using such technology application have guaranteed the lowering of prime cost of endoscopic intervention, in several patients it made possible to avoid a mechanical suturing application. After the operation all the patients are alive, the morbidity rate was 7.

[Experience of application of nonsuture electrowelding technologies in thoracic surgery].

Experience of application of nonsuture electrowelding technologies (NEWT) was analyzed while performing open and miniinvasive thoracoscopic operations in 116 patients. No essential differences were revealed while comparing domestic and foreign electrowelding surgical instruments. Possibility of wide application of NEWT in miniinvasive videothoracoscopic surgery was demonstrated.

[Peculiarities of the lower extremities perfusion in patients with complicated diabetic foot syndrome].

Analysis of the microcirculation indices in 246 patients, suffering diabetic foot syndrome (DFS), was presented. For a neuropathic form of DFS characteristic is lowering of the arterioles tone and enhancement of the blood volume in them, witnessed by raising of constant component of the blood flow. General worsening of perfusion is caused by lowering of endothelial secretion activation, and as well as neurogenic and myogenic control mechanisms.

[Effect of electromagnetic field of extremely low frequency on ATPase activity of actomyosin].

The Mg2+/Ca2+ and K(+)-ATPase actomyosin activity of rabbit skeletal muscle was evaluated by the Fiske-Subbarow method during a five-hour exposition of protein solutions in electromagnetic field of extremely low frequency of 8 Hz and 25 microT induction. The results of the study of the ATPase activity of actomyosin upon electromagnetic exposure have shown statistically significant changes that are characterized by a rather complex time dynamics. After 1, 2 and 4 hours of exposure of protein solutions the effect of ELF EMF exposure inhibits the ATPase activity compared to control samples, which are not exposed to the magnetic field.

[Possibilities of improving of videothoracoscopic operations for spontaneous pneumothorax].

A 15-years experience of videothoracoscopic operations in the treatment of 616 patients, suffering spontaneous pneumothorax, was summarized. The methods of videothoracoscopic operations, depending on the volume and localization of pathological process in pulmonary tissues, were depicted. The stages of endoscopic surgical intervention for spontaneous pneumothorax were analyzed.

[Video-assisted thoracoscopic surgeries for thoracic diseases and trauma].

The experience of videothoracoscopic operations, performed for various diseases of the thoracic organs, was summarized. The reduction of the operation traumaticity, the complications rate, lethality, the patients rehabilitation duration permits to consider videothoracoscopic operations as the method of choice in many thoracic diseases and trauma.

[Application of combined videothoracoscopic resection in thoracic surgery].

The method of combined videothoracoscopic atypical pulmonary resection, permitting to apply endostaplers and standard staplers in one intervention procedure, was elaborated. The method was applied in 47 patients in various pulmonary diseases without severe complications, all the patients are alive. Economic expedience of the method application, permitting to reduce usage of endostaplers, was shown.

[Application of early videothoracoscopic pulmonary decortication in the treatment of an acute pleural empyema and suppurated clotted hemothorax].

There was presented the experience of performance of videothoracoscopic pulmonary decortications in 22 patients, suffering suppurated clotted hemothorax, and in 188--an acute pleural empyema. In 97.3% patients the cessation of purulent process and pulmonary volume restoration were achieved.

[Possibilities of videothoracoscopic pulmonary resection in thoracic surgery].

The experience of videothoracoscopic pulmonary resection performance in various diseases in 183 patients was summarized. The methods of endoscopic and videoassisted pulmonary resection, including those conducted for peripheral cancer, using home-made and foreign suture apparatuses, were depicted. The indications were adduced for performance of diagnostic and curative videothoracoscopic operations, possibilities of their application, advantages in comparison with open operative procedures were adduced.

[Surgical treatment of non-tumorous stenosis of the esophagus].

Experience of different types of esophagoplasty at nontumours stenosis of esophagus at 61 patient is resulted. Possible variants of esophagoplasty are described by both a stomach and a colon, and also stages of implementation. The analysis of postoperation complications, probability of their origin depending on the method of esophagoplasty, possibility of prophylaxis is conducted.

[Role of video-assisted thoracoscopic operation in the treatment of later complications of the chest injury].

The experience reported of videothoracoscopical operations in 62 patients with late complications of chest trauma occurring after penetrating open wounds of chest--in 16 patients and in 46 one--with closed trauma. Good clinical effects achieved in 98% of the patients. The reported complications after video-assisted thoracoscopical operations--4 purulent inflammation of thoracoportal incisions, 3--marginal pleuritis.

[Endoscopic operations on the trachea and bronchi].

The experience of performance of 1425 endoscopic recanalization operations, done in 864 patients for the tumor and cicatricial stenosis of trachea and bronchi, was summarized. The methods were depicted of endoscopic destruction as a definite treatment or as a successful stage of the combined treatment. The possibility there was shown of the lasers and electrocoagulation application for the respiratory ways stenosis recanalization.

[The performance of video-assisted thoracoscopic operations for later complications of thoracic trauma].

There was presented the experience of videothoracoscopic operations performance in 62 patients, suffering late complications of thoracic trauma, which had occurred after perforating woundings--in 16 and the closed trauma--in 46. Good clinical effect was achieved in 98% of injured persons. All the patients are alive.