1-Peptidyl-2-arachidonoyl-3-stearoyl-sn-glyceride: an immunologically active lipopeptide from goat serum (Capra hircus) is an endogenous damage-associated molecular pattern.

Experiments were undertaken to isolate a component of the serum of goat (Capra hircus) that is effective at mediating an innate immune response. This report describes the isolation and structure elucidation of 1-(N-acetyl-ALYDKGYTSKEQKDCVGI)-2-arachidonoyl-3-stearoyl glyceride (1) and its immunomodulatory activity. A dose-response relationship for inflammatory cytokine and chemokine production and release from human fibroblasts incubated with nanomolar concentrations of 1 was shown.

Electron-Transfer Processes in Indium(II) Iodide-o-Quinone Systems.

Indium(II) iodide reacts with various substituted o-quinones in nonaqueous solution by successive one-electron-transfer reactions to give (SQ)InI(2) products (SQ = semiquinonate radical anion). Electron spin resonance spectroscopy demonstrates the presence of both mono- and diradical species in the reaction mixture. Addition of 4-picoline to a mixture of In(2)I(4) and TBQ (=3,5-di-tert-butyl-o-quinone) in toluene causes the precipitation of the indium(III)-semiquinonate complex (TBSQ)InI(2)(pic)(2) whose structure has been established by X-ray crystallography: space group P&onemacr;, with a = 13.