Effect of intraoperative heparin administration on some indices of the blood coagulatory-lytic system in the ischemic region of the small intestine with anastomosis.

Several parameters of blood coagulation-lytic system were estimated in an ischemic region of narrow intestine with anastomosis in absence of heparin therapy and after subcutaneous intraoperative heparin administration. Single heparin injection in high therapeutic doses (200 U/kg body weight) during the fi nal stage of surgery prevents not only thrombosis of mesenteric blood vessels, but to a certain extent intraperitoneal adhesions.

CF2Cl2 decomposition over nanocrystalline MgO: evidence for long induction periods.

CF(2)Cl(2) has been found to react with nanoscale MgO at 325 degrees C and higher temperatures. In excess of the halocarbon, the reaction results in the formation of MgF(2) as a predominant solid product, with CCl(4), and CO(2) formed as the main gaseous products. The kinetics of the process is characterized by a prolonged induction period, which is as long as 8.

Decontamination of gaseous acetaldehyde over CoOx-loaded SiO2 xerogels under ambient, dark conditions.

A series of CoO(x)-doped silica xerogels with various Co(2+) loadings (Co/Si = 0, 1, 2, 4, 6, and 10 mol %) has been prepared. All xerogels exhibit large (800-1050 m(2)/g) surface areas. Narrow pore size distributions with pore size maxima around 3 nm are characteristic for Co/Si = 1, 2, 4, 6, 10 samples.

Structural defects cause TiO2-based photocatalysts to be active in visible light.

Oxidation of TiO or Ti2O3 led to the formation of TiO2 with activity in visible light much higher than when TiN was used as a precursor, pointing out the importance of oxygen defects/vacancies for extension of activity of TiO2 into the visible region.

Influence of solution composition and ultrasonic treatment on optical spectra of TiO2 aqueous suspensions.

Investigation of TiO(2) aqueous suspensions has shown that their optical spectra can be unstable, with instability not related to precipitation or adherence of TiO(2) particles to the vessel walls. Increase of ionic strength of the suspension as well as neutralization of charged TiO(2) particles via pH adjustment accelerates the optical density drop. Vice versa, increasing the charge of TiO(2) particles via shifting pH in acidic or basic directions stabilizes the suspension's optical spectra, and ultrasonic treatment promotes optical density recovery.

Photocatalytic oxidation of gaseous 2-chloroethyl ethyl sulfide over TiO2.

Photocatalytic oxidation of gaseous 2-chloroethyl ethyl sulfide (2-CEES, ClCH2CH2SCH2CH3) over TiO2 illuminated with UV light and maintained at 25 or 80 degrees C in air has been investigated. 2-CEES was found to suffer progressive oxidation to yield ethylene (CH2CH2), chloroethylene (ClCHCH2), ethanol (CH3CH2OH), acetaldehyde (CH3C(O)H), chloroacetaldehyde (ClCH2C(O)H), diethyl disulfide (CH3CH2S2CH2CH3), 2-chloroethyl ethyl disulfide (ClCH2CH2S2CH2CH3), and bis(2-chloroethyl) disulfide (ClCH2CH2S2CH2CH2Cl) as the main primary intermediates, and water (H2O), carbon dioxide (CO2), sulfur dioxide (SO2), surface sulfate ions (SO4(2-)), and hydrogen chloride (HCl) as the final products. Trace concentrations of gaseous 2-chloroethanol (ClCH2CH2OH), ethanesulfonyl chloride (CH3CH2SO2Cl), ethyl thioacetate (CH3CH2SC(O)CH3), and considerable amounts of acetic acid (CH3C(O)OH), crotonaldehyde (CH3CHCHC(O)H), methyl acetate (CH3C(O)OCH3), and methyl formate (CH3OC(O)H) were also detected in the gas phase during the photooxidation conducted at 80 degrees C.

Synthesis and evaluation of oligo-1,3-thiazolecarboxamide derivatives as HIV-1 reverse transcriptase inhibitors.

A set of oligo-1,3-thiazolecarboxamide derivatives able to interact with the minor groove of nucleic acids was synthesized. These oligopeptides contained different numbers of thiazole units presenting dimethylaminopropyl or EDTA moieties on the C-terminus, and aminohexanoyl or EDTA moieties on the N-terminus. The inhibition of such compounds on HIV-1 reverse transcriptase activity was evaluated using different model template primer duplexes: DNA x DNA, RNA x DNA, DNA x RNA and RNA x RNA.

Interaction of oligonucleotides conjugated to substituted chromones and coumarins with HIV-1 reverse transcriptase.

Ten different pyranone-related substituents (chromones or coumarins) were covalently linked to the 5' end of various oligonucleotides (ODN). The interaction of these compounds with human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) was analyzed. A different behavior was found to depend on the structure of the oligonucleotide derivatives.

HIV-1 reverse transcriptase is capable of elongating derivatives of sequence specific noncomplementary oligodeoxynucleotides.

We have carried out a comparison of KM and Vmax values for various primers in the polymerization reaction catalyzed by the HIV-1 RT. The affinity of RT for complementary d(pT)6 containing two different 5'-end pyranone derivatives was 2-3 orders of magnitude higher (KM = 3-15 nM) than that of d(pT)6 (KM = 12.6 mM).