Chemiluminescent Analysis of Oxidative Metabolism in Rat Blood under the Influence of Argon and Helium.

We studied the nature of the action of course treatment with argon and helium (1 min, 3 procedures) on the oxidative metabolism in rat blood plasma. The study was performed on 30 Wistar rats divided into 3 groups (n=10 in each group): intact and 2 experimental (treatment of the skin of the back with a stream of argon and helium, respectively). After completion of the treatment course, the intensity of free radical processes, the total antioxidant activity, and malondialdehyde concentration were evaluated in the blood plasma.

Molecular Hydrogen: From Molecular Effects to Stem Cells Management and Tissue Regeneration.

It is known that molecular hydrogen is a relatively stable, ubiquitous gas that is a minor component of the atmosphere. At the same time, in recent decades molecular hydrogen has been shown to have diverse biological effects. By the end of 2022, more than 2000 articles have been published in the field of hydrogen medicine, many of which are original studies.

Near-Field Microwave Tomography of Biological Tissues: Future Perspectives.

This overview shows the mapping of specific visualization techniques, depth assessment of the structure of the underlying tissues and used wavelengths of radiation. Medical imaging is currently one of the most dynamically developing areas of medical science. The main aim of the review is a systematization of information on the current status of the microwave imaging of biological objects, primarily of body tissues.

Spectroscopy of Laser-Induced Dielectric Breakdown Plasma in Mixtures of Air with Inert Gases Ar, He, Kr, and Xe.

The generation of ozone and nitrogen oxides by laser-induced dielectric breakdown (LIDB) in mixtures of air with noble gases Ar, He, Kr, and Xe is investigated using OES and IR spectroscopy, mass spectrometry, and absorption spectrophotometry. It is shown that the formation of NO and NO noticeably depends on the type of inert gas; the more complex electronic configuration and the lower ionization potential of the inert gas led to increased production of NO and NO. The formation of ozone occurs mainly due to the photolytic reaction outside the gas discharge zone.

Some Beneficial Effects of Inert Gases on Blood Oxidative Metabolism: Study.

The aim of the study was to assess the effect of external use of inert gases (helium and argon) on the state of free radical processes in vivo. The experiment was performed on 30 male Wistar stock rats (age-3 months, weight-200-220 g.), randomly distributed into 3 equal groups.

Cold Argon Athmospheric Plasma for Biomedicine: Biological Effects, Applications and Possibilities.

Currently, plasma medicine is a synthetic direction that unites the efforts of specialists of various profiles. For the successful formation of plasma medicine, it is necessary to solve a large complex of problems, including creating equipment for generating cold plasma, revealing the biological effects of this effect, as well as identifying and justifying the most promising areas of its application. It is known that these biological effects include antibacterial and antiviral activity, the ability to stimulate hemocoagulation, pro-regenerative properties, etc.

Experimental Evaluation of the Effect of Argon Cold Plasma on Oxidative Metabolism of the Blood.

We studied the effect of course exposure to argon cold plasma (ten 1- and 2-min procedures) on some parameters of the oxidative metabolism of rat blood plasma. The intensity of free radical processes, the total antioxidant activity, and malondialdehyde concentration in rat plasma were evaluated. It was found that 2-min exposure to argon cold plasma and nonionized argon stream produce a prooxidant effect, while 1-min exposure argon plasma led to stimulation of the antioxidant reserves of the blood.

An anthropogenic model of cardiovascular system adaptation to the Earth's gravity as the conceptual basis of pathological anthropology.

Applying human biological evolution to solve topical problems of medicine and preventive cardiology was inspired by the realization of the need for clinical and experimental studies of biological (evolutionary) prerequisites in the occurrence of a pathology. Although it has been stated that there is a need to provide a full biological understanding of features, including those that increase an animal's vulnerability to diseases, unfortunately, in this regard, erectile and associated adaptations to the Earth's gravity in their physiological and pathological manifestations have not been considered. At the same time, it should be noted that humans, unlike other animal species, have the greatest vulnerability of the cardiovascular system (CVS).

[Metabolic estimation of efficiency of vitamin and mineral complexes in qualified athletes].

In professional athletes who adapt to intense physical training and psycho-emotional stress, the formation of oxidative stress is shown. This fact determines the expediency of targeted correction of disorders of the balance of pro- and antioxidant systems in blood and tissues caused by intense physical training. of the work was to study the effect of vitamin-mineral complex on the parameters of oxidative blood metabolism in professional athletes.

Cohort study of microelement status in "healthy" population of Russian megapolis.

The aim of the study was at the cohort assessment of microelement status in large city residents classified as "apparently healthy people". The population study included 2,025 randomly selected middle-aged (2045 years) persons without chronic diseases or acute infectious pathologies. The set of subjects was standardized by age and gender.

Effects of Helium Cold Plasma on Erythrocyte Metabolism.

The effects of helium cold plasma on some parameters of metabolism of rat erythrocytes were studied after a course exposure (10 daily procedures, 1 min each). The intensity of free-radical processes in erythrocyte membranes, malondialdehyde concentration, and aldehyde dehydrogenase activity were analyzed. The exposure to helium cold plasma led to a significant increase in malondialdehyde level mostly associated with inhibition of its utilization.

Effects of Physiological Nitric Oxide Donor on Oxidative Metabolism in Rat Blood.

The effects of exogenous dinitrosyl iron complexes with glutathione ligands on the parameters of oxidative metabolism in the rat blood are studied. The intensity of LPO, total antioxidant activity, and MDA level in the plasma are compared in rats receiving intraperitoneal injections of saline without and with dinitrosyl iron complexes in various concentrations (0.15, 0.

[Analysis of the clinical efficiency of eradication therapy in patients with coronary heart disease associated with gastroduodenal pathology].

Aim: To comparatively analyze the clinical efficiency of eradiation therapy (ET) in patients with coronary heart disease (CHD) concurrent with gastroduodenal pathology (GDP).

Subjects And Methods: The study was conducted in three steps. In Step 1, 1588 patients with chronic CHD were examined.

Effect of ROS Inhalation on Systemic and Local Hemodynamics in Rats.

The effects of inhalation of singlet oxygen mixture, dry and humidified ozone-oxygen mixture, and ozonated oils on heart rate variability as well as on the rate and control mechanisms of microcirculation were examined in rats. The most optimal were the responses of systemic and regional hemodynamics to inhalation of the gas produced by a generator of singlet oxygen and humidified ozone-oxygen mixtures. Singlet oxygen stabilized the cardiac rhythm and augmented microcirculation via activation of "internal" (endothelial and neurogenic) regulatory mechanisms.

Modification of the Catalytic Properties of Erythrocyte Aldehyde Dehydrogenase in Rats after Nitric Oxide Inhalation.

We studied aldehyde dehydrogenase activity in erythrocytes from healthy rats and animals with thermal trauma after NO inhalation. NO had an activating effect on catalytic properties of aldehyde dehydrogenase in healthy rats and burned animals. The effect of NO was more pronounced during burn disease.

[Nitric Oxide in Modulation of Crystallogenic Propeties of Biological Fluid].

The aim of this work was a comparative analysis of the influence of different NO forms on dehydration structurization of human blood serum. Blood specimens from 15 healthy people were treated by NO-containing gas flow (800 and 80 ppm) generated with the "Plazon" unit, experimental NO-generator (20, 50, 75 and 100 ppm) and by water solution of thiol-containing dinitrosyl iron complexes (3 mM/L). The influence of blood sodium on blood serum crystallization in original and NO-treated blood specimens was estimated.

[INFLUENCE OF DINITROSYL IRON COMPLEXES ON OXIDATIVE METABOLISM UNDER EXPERIMENTAL THERMAL TRAUMA CONDITIONS].

We have studied the effect of dinitrosyl iron complexes (DNIC) on blood lipid peroxidation and antioxidant system under experimental thermal trauma (burn) conditions in three groups of rats, each containing 10 animals. Group 1 was intact control, groups 2 and 3 were subjected to model thermal trauma, and group 3 were daily intraperitoneally injected with 3 ml of 0.3 mM of aqueous DNIC solution for 10 days.

[Comparative analysis of action of nitric oxide as a free radical and its storage form on the state of pro- and antioxidant blood systems].

The dynamics of oxidative metabolism in healthy people's blood (n = 30) under the influence of gaseous nitric oxide and dinitrosyl iron complexes is explored. In all blood samples we studied lipid peroxidation intensity and malonic dialdehyde in plasma and erythrocytes, plasma antioxidant potential and activity of superoxide dismutase. During our investigations it was possible for the first time to identify the peculiarities in the responses of pro- and antioxidant blood systems in vitro to the treatment with nitrogen monoxide as the free.

[Influence of nitric oxide inhalations on oxidative and energy metabolism of blood in rats].

The aim of this work was the investigation of nitric oxide (NO) inhalations action on some parameters of energy and oxidative metabolism of healthy rats blood. Wistar rats were randomly divided into two groups: control group (without any manipulations; n = 10) and main group (n = 10) with inhalations by NO-containing gas flow (20 ppm). Activity of pro- and antioxidant systems, superoxide dismutase, lactate dehydrogenase and lactate level were estimated in rats blood samples.

[Influence of dinitrosyl iron complexes on blood metabolism in rats with thermal trauma].

The dynamics in the oxidative and energy metabolism and enzyme systems of blood detoxification in animals with thermal trauma injected with dinitrosyl iron complexes was explored. The positive effect of dinitrosyl iron complexes on the state of blood pro- and antioxidant systems in animals with experimental thermal injury having profound oxidative stress is shown. This effect is observed as a considerable reduction of the intensity (normalization) of lipid peroxidation processes against significant elevation of antioxidant potential of blood plasma.

[Studying the influence of some reactive oxygen species on physical and chemical parameters of blood].

The aim of this work was to estimate the dynamics of blood physical and chemical parameters when blood specimens were processed by singlet oxygen in vitro. Our experiments were executed with whole blood specimens of healthy people (n=10). Each specimen was divided into five separate portions of 5 ml.

[Modification of blood plasma crystallogenesis with nitrogen oxide processing].

The aim of this work is to estimate crystallogenic properties of human blood serum processed by gas nitric oxide. Blood samples of ten healthy patients were processed by cold plasma with NO (800 mcg/l). The true and initiated (by 0.

Influence of NO-containing gas flow on various parameters of energy metabolism in erythrocytes.

We studied the influence of NO-containing gas phase on some parameters of energy metabolism in human erythrocytes. Whole blood samples were aerated with gas flows from the Plazon instrument (NO concentrations 800 and 80 ppm) and from the experimental generator (75 ppm). Activity of lactate dehydrogenase in direct and reverse reactions, lactate level, and a number of derived coefficients were estimated.

[Effect of phytic acid and its derivatives on blood lipid peroxidation state in vitro].

We have studied specific features of lipid peroxidation in whole human blood under the action of aqueous solutions of xymedone (19.6 microM), phytic acid (117.9 microM) and its complex (237.

The study of the complexes of nitromedicine with cytochrome c and NO-containing aqueous dosage form in the wound treatment of rats.

The interaction of cytochrome c with nitromedicines, such as 5-nitrofural, 5-nitroxoline, metronidazole and sodium nitrite which enables the generation of nitric oxide or nitrosyl complexes in the presence of ascorbic acid or sodium ascorbate in acid medium has been investigated. The pharmaceutical compositions containing cytochrome c and nitromedicine complexes as active substances were studied in the experiments by using rats. It has been shown that positive local and systemic effects were estimated when NO-containing gel was used at burn treatment.