Curvilinear bodies in hydroxychloroquine-induced renal phospholipidosis resembling Fabry disease.

Inherited and acquired metabolic disorders are responsible for renal intracellular accumulation of phospholipids. Ultrastructural analysis revealing typical myeloid or zebra bodies was previously thought to be exclusive to Fabry disease. However, chloroquine/hydroxychloroquine toxicity can cause similar abnormalities.

Metanephric adenoma-like tumors of the kidney: report of 3 malignancies with emphasis on discriminating features.

Background: Metanephric adenoma is a very rare benign renal tumor; only 80 well-documented cases have been reported to date. We have seen several renal tumors that were originally incorrectly diagnosed as metanephric adenoma.

Design: We present 3 unusual renal tumors (2 primary and 1 metastatic), each of which illustrates important pathologic features useful in discriminating metanephric adenoma from malignant mimics.

Functional, histologic, and ultrastructural study of the protective effects of verapamil in experimental ischemic acute renal failure in the rabbit.

The present study was performed in vivo in rabbits to evaluate the functional and morphologic effects of verapamil in a model of ischemic acute renal failure (ARF). Particularly impressive was the ultrastructural integrity of renal tubules in the animals exposed to both ischemia and verapamil. Three groups were studied: Group A: no ischemia; Group B: renal ischemia alone; and Group C: renal ischemia with verapamil.

[Clinical presentation and prognostic factors in primary hemolytic-uremic syndrome in adults].

The clinical presentation and prognostic determinants in a group of 20 patients who presented a hemolytic-uremic syndrome for a period of 14 years are reviewed. Patients younger than 10 years old and those with and hemolytic-uremic syndrome due to a systemic disease, renal transplant or accelerated arterial hypertension were excluded from the study. The clinical picture consisted mainly of renal, hematological, hemorrhagic, neurologic cardiovascular, gastrointestinal and hepatic manifestations.

Histopathologic variability of the congenital nephrotic syndrome.

Five cases of congenital nephrotic syndrome (CNS) were studied with light microscopic (LM), transmission electron microscopic (TEM) and immunofluorescence microscopic (IFM) techniques. All patients, aged between three weeks and one year, had a nephrotic syndrome (NS) and died soon after the diagnosis. Three patients showed mesangial proliferation, thinning of glomerular basement membranes (GBM) and no deposits by IFM or TEM.

Tricuspid atresia. An anatomical study of 17 cases.

This is a report on the anatomical characteristics of 17 cases of tricuspid atresia. Three of these cases had a discrepancy between the type of bulboventricular loop (dextro) and the position of the great arteries (the aorta being to the left of the pulmonary artery). In these a characteristic type of ventricular septal defect, located just beneath the tissue of the semilunar valves was found.