Publications by authors named "Martti E Heikkinen"
Clozapine is associated with significant weight gain and metabolic disturbances. This multicentre, randomized study comprised a double-blind, placebo-controlled treatment phase of 16 wk, and an open-label extension phase of 12 wk. Outpatients who met DSM-IV-TR criteria for schizophrenia, who were not optimally controlled while on stable dosage of clozapine for > or =3 months and had experienced weight gain of > or =2.
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- The study examined life events and social support among 269 patients diagnosed with major depressive disorder, revealing that most reported experiencing significant life events prior to their depression.
- Findings indicated no major differences based on demographic or clinical factors, though younger patients reported more events and those with comorbid conditions perceived lower social support.
- Life events were consistently distributed across the periods leading up to and during depression, with two-thirds of patients attributing their condition to specific events; overall, the patient group showed homogeneity in their experiences.