Publications by authors named "Martinus de Kruijff"
Specialized or secondary metabolites are small molecules of biological origin, often showing potent biological activities with applications in agriculture, engineering and medicine. Usually, the biosynthesis of these natural products is governed by sets of co-regulated and physically clustered genes known as biosynthetic gene clusters (BGCs). To share information about BGCs in a standardized and machine-readable way, the Minimum Information about a Biosynthetic Gene cluster (MIBiG) data standard and repository was initiated in 2015.
View Article and Find Full Text PDFFeature-based molecular networking (FBMN) is a popular analysis approach for liquid chromatography-tandem mass spectrometry-based non-targeted metabolomics data. While processing liquid chromatography-tandem mass spectrometry data through FBMN is fairly streamlined, downstream data handling and statistical interrogation are often a key bottleneck. Especially users new to statistical analysis struggle to effectively handle and analyze complex data matrices.
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- β-Amino acid-containing macrolactams are bioactive compounds derived from polyketides, but there's limited understanding of their prevalence and biosynthetic diversity among bacteria.
- This study used a specialized search method to find bacterial strains capable of producing these macrolactams, revealing that about 10% of certain actinobacterial genera have the necessary gene cluster for macrolactam production.
- The research identified mutations in polyketide synthases as key factors influencing macrolactam diversity, validated known producers like ciromicin A, and discovered new variants of macrotermycins, enhancing methods for future macrolactam discovery.