Coregistration of preoperative computed tomography and intraoperative three-dimensional rotational x-ray images for cochlear implant surgical evaluation.

Objective: A registration procedure of intraoperative three-dimensional rotational x-ray (3DRX) imaging and preoperative computed tomography (CT) imaging so that intraoperative CT quality imaging is available during cochlear implant surgery, providing detailed information concerning electrode position in the cochlea and its relation to surrounding bony structures.

Study Design: Retrospective case series

Setting: Tertiary referral center

Data: The imaging of five patients who had undergone cochlear implant surgery is used to develop a semiautomatic registration procedure to integrate intraoperative 3DRX and preoperative CT. The method is implemented in advanced medical imaging software to compute the transformations.

The peripheral processes of spiral ganglion cells after intracochlear application of brain-derived neurotrophic factor in deafened guinea pigs.

Objective: To characterize the effects of deafening and subsequent treatment with brain-derived neurotrophic factor (BDNF) on the peripheral processes (PPs) of spiral ganglion cells (SGCs) in guinea pigs.

Background: BDNF may prevent degeneration of neural structures after loss of hair cells with possible relevance for cochlear implant candidates.

Methods: Guinea pigs were deafened with a combination of kanamycin and furosemide.