Effectors and predictors of conceptus survival in cattle: What is next?

In cattle, the physiological process of switching from cycling to pregnant is complex. Ultimately, that process relies on endometrial luminal epithelial cells and is based on the paracrine context of the uterine lumen. Cells either release luteolytic pulses of prostaglandin F2 alpha to keep the animal cycling or respond to cues released by the elongated conceptus that block prostaglandin F2 alpha pulses to maintain luteal function and pregnancy.

Evaluation of a DNA vector plasmid encoding a partial rop18 gene from toxoplasma gondii in domestic cats as a vaccine candidate.

The present study aimed to evaluate a DNA vector plasmid encoding a partial rop18 gene from Toxoplasma gondii in domestic cats as a potential vaccine candidate. Four domestic cats (Felis catus) were used, of which two animals received 25 μg of pcDNA 3.1 + rop18, and two received 25 μg of pcDNA 3.

Vertical transmission of Neospora caninum from three generations of naturally infected dairy cattle from Brazil.

Neospora caninum is a major cause of abortion in dairy cattle, and vertical transmission is considered the most relevant route. The present study aimed to evaluate the vertical transmission of N. caninum from three generations of naturally infected dairy cows.

Sodium Cholate-Mediated Ion-Pairing for Skin Delivery of Methylene Blue: Physicochemical Characterization and Influence on Skin Barrier and Skin Penetration.

Methylene blue (MB)-based photodynamic therapy has proven to be effective and promising for the treatment of non-melanoma skin neoplasms. However, the topical application of MB has certain challenges. MB is a cationic and water-soluble molecule.

Management of dropped head syndrome: a systematic review and single-arm meta-analysis.

Dropped Head Syndrome (DHS) is a rare condition marked by severe neck extensor muscle weakness, leading to a chin-on-chest deformity caused by pathological kyphosis. This study aims to evaluate the efficacy of conservative versus surgical treatments for DHS. A systematic search of PubMed, Embase, and ScienceDirect was conducted for studies on DHS treatments.

Shaping future professionals: the role of mentoring in graduate education and career development.

Graduate students play a pivotal role in advancing science, education, and extension, particularly in the field of animal and dairy sciences. As expectations on faculty productivity rise, effective mentoring becomes crucial for shaping future professionals and supporting institutional goals. This article emphasizes the distinction between academic advisors and mentors, arguing that while advisors guide short-term academic objectives, mentors foster long-term personal and career development.

Cumulative effect of photobiomodulation by blue and red light on tumor cells: in vitro study with mammary adenocarcinoma cells - MCF-7.

Although the mechanism of action of photobiomodulation (PBM) on tumor cells is already well described in the literature, its cumulative effect is not. The purpose of this study was to evaluate the cumulative effect of photobiomodulation (PBM) with blue (470 nm) and red (658 nm) light at doses of 6 J/cm² and 19 J/cm², respectively, in mammary adenocarcinoma (MCF-7) tumor cells. The study analyzed how single and sequential exposures to these lights modulated cell viability, proliferation, dsDNA release, nitric oxide (NO) production, and reactive oxygen species (ROS).

Isolation and Biosynthesis of Hyellamide, a Glycosylated N-Acyltyrosine Derivative, from the Cyanobacterium LEGE 07179.

Recent analyses of genome data indicate that members of the cyanobacterial order Pleurocapsales show tremendous potential for natural product discovery. However, only a few compounds have been reported from this order. Here, we report the isolation of hyellamide (), a glycosylated N-acyl tyrosine-derived eneamide, from the pleurocapsalean cyanobacterium LEGE 07179.

Alichondrichlorin, a Novel Chlorohydrin-Containing Natural Product With Tumoral Cytotoxic Activity Isolated From the Planctomycetota Bacterium Alienimonas chondri LzC2.

To address the on-going need for chemical novelty and the limited information on Planctomycetota secondary metabolism, we focused on exploring the recently isolated marine planctomycetal strain Alienimonas chondri LzC2 to uncover its potential production of novel compounds. This work contemplates the description of a large-scale cultivation study of strain LzC2, followed by metabolite extraction and compound isolation using chromatographic approaches, which resulted in the isolation of a novel molecule designated as alichondrichlorin. Structural elucidation of this new molecule was accomplished by a combination of high-resolution mass spectrometry and nuclear magnetic resonance.

Effects of physical exercise in reducing caregivers burden: a systematic review.

Background And Aim: Caring for someone can be physically and psychologically demanding, predisposing caregivers to muscle injuries, fatigue, exhaustion, depression, anxiety, and burnout. The literature suggests several approaches to reducing caregiver burden, one of which is physical exercise. The aim of this systematic review was to analyze the effectiveness of exercise-based programs or muscle relaxation in reducing caregiver burden and stress among family caregivers.

[Child and adolescent mental health: analysis of therapeutic itineraries in an inner municipality without Child and Adolescent Psychosocial Care Centers].

Research on therapeutic itineraries in child and adolescent mental health has been predominantly carried out in Child and Adolescent Psychosocial Care Centers or in regions that have these services. To expand the understanding of this field, this study analyzed the therapeutic itineraries of children and adolescents assisted by the Multiprofessional Mental Health Team service - locally known as "Mental Health" - in an inner municipality without Child and Adolescent Psychosocial Care Centers. Semistructured interviews were conducted with 12 mothers and two fathers to understand their motivations for seeking care, the places they visited, and the experiences they had in this process.

Predicting Atrial Fibrillation Relapse Using Bayesian Networks: Explainable AI Approach.

Background: Atrial fibrillation (AF) is a prevalent arrhythmia associated with significant morbidity and mortality. Despite advancements in ablation techniques, predicting recurrence of AF remains a challenge, necessitating reliable models to identify patients at risk of relapse. Traditional scoring systems often lack applicability in diverse clinical settings and may not incorporate the latest evidence-based factors influencing AF outcomes.

Mapping the viral battlefield: SARS-CoV-2 infection dynamics among healthcare workers in Brazil.

Background: Understanding the dynamics of SARS-CoV-2 viral infection and factors associated with in-hospital transmission rates among healthcare workers (HCW) is crucial for their protection. Brazil experienced high mortality rates due to COVID-19, and limited data are available on transmission of SARS-CoV-2 infection among HCW. This cohort study aimed to assess the dynamic of SARS-CoV-2 infections in HCW from two tertiary hospitals in central Brazil, one of them a Reference Hospital for COVID-19.

Synthesis and application of calcium cyclotriphosphate in bleaching formulations: Effects on dental enamel properties.

Objectives: This study aimed to synthesize and evaluate the in vitro effects of varying concentrations (0.25%, 0.5%, and 1%) of calcium-substituted sodium trimetaphosphate (CaNaTMP) incorporated into 17.

Clinical efficacy of adjunctive use of coenzyme Q10 in non-surgical periodontal treatment: A systematic review.

This systematic review evaluated the effects of coenzyme Q10 (CoQ10) in non-surgical periodontal treatment (PROSPERO: CRD42022311286). Five databases were screened (up to May/2024). It included only randomized controlled trials (RCTs) of subgingival scaling root planing (SRP) with or without adjunct use of the antioxidant CoQ10 in adults with periodontitis.

Morphometric analysis of the greater palatine foramen: a CBCT study in Portugal.

Purpose: The greater palatine foramen (GPF) represents the inferior opening of the greater palatine canal and is located posterolaterally on both sides of the hard palate. The aim of this study is to morphometrically characterise the GPF and to determine its anatomical relationships in a Portuguese population.

Methods: A retrospective study was performed based on the clinical records which included all permanent teeth erupted and a cone beam computed tomography (CBCT) of the entire maxilla.

Evaluating the Effectiveness of Primary Care Health Checks at Assessing Cardiovascular Risks among Ethnic Minorities in the UK: A Systematic Review.

Background: Cardiovascular diseases (CVD) affect around 7.6 million people in the UK, disproportionately affecting the minority ethnic community. In 2009, the UK's National Health Service (NHS) launched a Health Check (NHSHC) scheme to improve early diagnosis of various clinical conditions, including CVD, by screening patients for associated risk factors.

Impact of social isolation during the COVID-19 pandemic on the mental health of university students and recommendations for the post-pandemic period: A systematic review.

Introduction: Investigating the psychological impact caused by the interruption of social interactions on university students during the pandemic is essential, with a view to developing strategies to preserve mental health and academic performance.

Objective: To analyze the impact of social isolation during the COVID-19 pandemic on the mental health of university students and propose recommendations for the post-pandemic period.

Method: This systematic review was conduced in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and was registered in the International Prospective Register of Systematic Reviews (PROSPERO).

Video classes for adolescent nursing consultations: development and validation.

Objective: Create and validate the content of video lessons to support nurses when carrying out adolescent consultations in Primary Health Care.

Method: Methodological research carried out in four stages: 1) Exploration, with 83 nurses and two literature narrative reviews; 2) Construction of scripts and storyboards; 3) scripts and storyboards' content validation; 4) Video classes production. Data analysis was conducted using the Content Validity Index.

Integrating biomarkers for hemostatic disorders into computational models of blood clot formation: A systematic review.

In the pursuit of personalized medicine, there is a growing demand for computational models with parameters that are easily obtainable to accelerate the development of potential solutions. Blood tests, owing to their affordability, accessibility, and routine use in healthcare, offer valuable biomarkers for assessing hemostatic balance in thrombotic and bleeding disorders. Incorporating these biomarkers into computational models of blood coagulation is crucial for creating patient-specific models, which allow for the analysis of the influence of these biomarkers on clot formation.

Determination of Positivity Cutoff for an Automated Aspergillus fumigatus-Specific Immunoglobulin-G Assay in a National Reference Laboratory.

Background: Detection of serum-specific immunoglobulin G (sIgG) to Aspergillus fumigatus traditionally relied on precipitin assays, which lack standardization and have poor analytical sensitivity. Automated quantitative immunoassays are now more widely used alternatives. A challenge, however, is determining reference interval (RI) cutoffs indicative of disease presence.