The economic burden of breast cancer in western Iran: a cross-sectional cost-of-illness study.

Background: Breast cancer is a significant global health challenge, affecting millions annually and imposing a considerable burden on healthcare systems and economies worldwide. This cross-sectional study aims to determine the economic impact of breast cancer in Lorestan Province, western Iran.

Methods: A retrospective cost-of-illness analysis utilizing a cross-sectional design was performed from November 2023 to July 2024.

Evaluating the impact of changing inhaler color on perception of symptoms and disease burden in patients with asthma: the FEEL study.

Objectives: Patient perception of treatment effectiveness is key to optimizing adherence. This is potentially impacted by color, yet no such studies have been conducted in asthma. This study assessed the influence of pink vs.

Impact of Physiotherapy on Shoulder Kinematics in Swimmers with Swimmer's Shoulder Pain.

Swimmer's shoulder is a common condition among elite swimmers, often leading to pain and reduced performance. Fatigue can exacerbate this condition by affecting shoulder strength, proprioception, and range of motion, potentially increasing the risk of overuse injuries. This preliminary study aimed to evaluate the impact of physiotherapy treatment and the effects of fatigue on shoulder kinematics using inertial and magnetic measurement units (IMUs).

Assessing equity in the distribution of hospital beds in Lorestan, western Iran: a regional analysis.

Background: Equity in health service delivery ensures that resources are distributed based on need, minimizing barriers to access and reducing health disparities. Hospital beds are a critical healthcare resource, essential for providing timely and effective medical care. This study aims to evaluate the equity in the distribution of hospital beds in Lorestan Province, western Iran, using the Gini coefficient and Lorenz curve as analytical tools.

Barriers and challenges of establishing family physician policy for urban population; evidence from a qualitative study in Iran.

Background: Family physicians play a crucial role in healthcare delivery systems worldwide. In Iran, the family physician program has been introduced in only two provinces, with its expansion to other regions currently stalled due to various challenges. This study aims to identify the barriers and challenges hindering the effective implementation of the family physician program in urban areas of Iran.

A historico-medical perspective on ancient epidemics and their impact on past human societies.

The present article reviews the major historical plague epidemics that characterised human history by combining data derived from historical sources and biomedical evidence emerged in recent years thanks to advancements of palaeogenetics and palaeopathology. Notes are offered on the Plague of Athens, the Antonine Plague, the Plague of Cyprian, the Justinian Plague, the Black Death down to more recent centuries and presenting key aspects that continued to be preserved over time and would also partly characterise the recent COVID-19 pandemic.

Metabolic plasticity in pancreatic cancer: The mitochondrial connection.

Background: Cellular metabolism plays a pivotal role in the development and progression of pancreatic ductal adenocarcinoma (PDAC), with dysregulated metabolic pathways contributing to tumorigenesis and therapeutic resistance. Distinct metabolic heterogeneity in pancreatic cancer significantly impacts patient prognosis, as variations in metabolic profiles influence tumor behavior and treatment responses.

Scope Of The Review: This review explores the intricate interplay between mitochondrial dynamics, mitophagy, and cellular metabolism in PDAC.

Strain Analysis for Early Detection of Fibrosis in Arrhythmogenic Cardiomyopathy: Insights from a Preliminary Study.

Arrhythmogenic cardiomyopathy (ACM) is a genetic disorder characterized by fibrofatty replacement of myocardial tissue, predominantly affecting the right ventricle (RV), but often involving the left ventricle (LV) as well. The early detection of fibrosis, crucial for risk stratification, has been enhanced by advanced imaging techniques. Global longitudinal strain (GLS) has shown promise as a surrogate marker for late enhancement (LE) in identifying myocardial fibrosis, yet precise cut-off values for strain are lacking.

Impact of contrast administration and CT reconstruction plane on Hounsfield units for assessing underlying bone quality in the lumbar spine.

Objective: Hounsfield units (HUs) may better predict biomechanical complications of instrumented fusion than conventional bone quality measures. Typically, noncontrast axial slices are used. This study aims to address the influence of reconstruction plane and contrast administration on measured HUs in patients undergoing lumbar spine imaging.

Colorectal cancer patients-derived immunity-organoid platform unveils cancer-specific tissue markers associated with immunotherapy resistance.

Colorectal cancer (CRC) is a devastating disease, ranking as the second leading cause of cancer-related deaths worldwide. Immune checkpoint inhibitors (ICIs) have emerged as promising treatments; however, their efficacy is largely restricted to a subgroup of microsatellite instable (MSI) CRCs. In contrast, microsatellite stable (MSS) CRCs, which account for the majority of cases, exhibit variable and generally weaker response to ICIs, with only a subset demonstrating exceptional responsiveness.

Factors driving misinformation production and user engagement with toothache content on Facebook.

This study characterized toothache-related Portuguese Facebook posts, identifying factors driving misinformation production and user engagement. Investigators qualitatively analyzed 500 posts published between August 2018 and August 2022, screening on language and theme. Posts were selected using CrowdTangle and assessed for motivation, author profile, content, sentiment, facticity, and format.

The effects of a short exercise bout on executive functions in healthy older adults.

Regular physical activity is associated with healthier brains and improved cognition among older adults. Yet, the impact of a short bout of exercise on older adults' cognition still is not fully clarified. The present study explored the effects of 20 min of moderate-intensity aerobic exercise (on a cycle ergometer) on cognition.

Immunoexpression of autophagy‑related proteins in a single‑center series of sporadic adult conventional clival chordomas.

Autophagy is a biological process that facilitates the degradation and removal of damaged structures and macromolecules. In neoplasms, autophagy has been proposed to play a dual role, functioning either as a tumor promoter or a tumor suppressor. To date, no comprehensive analysis of autophagy, primarily through immunohistochemical investigation of autophagy-related proteins (ATGs), has been conducted in chordomas (CHs), which are rare bone tumors that arise from remnants of the notochord.

A narrative review on allergy and exposure to domestic and non-domestic animals: favorable and unfavorable effects.

The aim of this contribution was to highlight the "favorable" and "unfavorable" roles of domestic and non-domestic animals on airway sensitization processes and on the type/severity of the clinical symptoms induced by their exposure. We performed a literature research in MEDLINE for allergic manifestations and animals. Pets can be "allergy friends" through mechanisms related to hygiene hypothesis and translational aspects, the dual role of IgG4 antibodies for pets, and their promising role as healthcare service animals (dogs).

The modernity of Achille Sclavo's (1861-1930) message for Italian schools 100 years after the publication of his book .

A hundred years ago, Achille Sclavo (1861-1930) published his book entitled "Per la Propaganda igienica. Scuola e Igiene" (The Propagation of Hygiene. Schools and Hygiene) which he dedicated "To elementary teachers, from whom Italy expects the most effective propaganda in favor of hygiene".

The fight against smallpox during the Savoy kingdom in Genoa between 1815 and 1859.

Introduction: The article aims to outline the features of the efforts for smallpox eradication within the pre-unitary context of the Kingdom of Sardinia, characterized by a long tradition in medical-health prevention. This tradition is partly inherited from the health magistracies of the Italian states during the ancient regime and partly adopted from policies initially outlined by Napoleon and later by other European states. In addition to prevention activities, authorities also engage in a vigorous information and awareness campaign aimed at eliminating common prejudices and doubts about vaccination among the population.

Violence against healthcare workers during the phases of the COVID-19 Pandemic: a descriptive observational study from 2018 to 2023 in the metropolitan city of Genoa (North-Western Italy).

Background: Violence against healthcare workers is an escalating public health concern, affecting the quality of care, and causing significant psychological and physical effects on healthcare professionals. This study analysed the trend in aggressions in healthcare settings in the pre-pandemic, pandemic, and post-pandemic periods.

Methods: An observational descriptive study was conducted to analyse reports of violence against healthcare workers from January 2018 to June 2023 at a Local Health Authority "ASL3" in the Liguria region of Italy.

Bonding and parent-child quality of interaction in parents with eating disorder: A scoping review.

Objective: To summarise existing evidence on bonding and parent-child quality of interaction in parents with eating disorder (ED).

Methods: A scoping review was conducted. Seven databases (PsycInfo, Embase, Medline, Pubmed, OpenGrey, ProQuest and Google Scholar) were examined and studies exploring research into bonding and quality of interaction in parents with ED were included.