OpaR Exerts a Dynamic Control over c-di-GMP Homeostasis and Expression in through Its Regulation of ScrC and the Trigger Phosphodiesterase TpdA.

The second messenger cyclic dimeric GMP (c-di-GMP) plays a central role in controlling decision-making processes that are vitally important for the environmental survival of the human pathogen Vibrio parahaemolyticus. The mechanisms by which c-di-GMP levels and biofilm formation are dynamically controlled in V. parahaemolyticus are poorly understood.

Emerging Evidence on the Use of Probiotics and Prebiotics to Improve the Gut Microbiota of Older Adults with Frailty Syndrome: A Narrative Review.

Background: The gut microbiota can impact older adults' health, especially in patients with frailty syndrome. Understanding the association between the gut microbiota and frailty syndrome will help to explain the etiology of age-related diseases. Low-grade systemic inflammation is a factor leading to geriatric disorders, which is known as "inflammaging".

Advances and challenges in the detection of academic stress and anxiety in the classroom: A literature review and recommendations.

In recent years, stress and anxiety have been identified as two of the leading causes of academic underachievement and dropout. However, there is little work on the detection of stress and anxiety in academic settings and/or its impact on the performance of undergraduate students. Moreover, there is a gap in the literature in terms of identifying any computing, information technologies, or technological platforms that help educational institutions to identify students with mental health problems.

Reliability and Usability Analysis of an Embedded System Capable of Evaluating Balance in Elderly Populations Based on a Modified Wii Balance Board.

This paper analyzes the reliability and usability of a portable electronic instrument that measures balance and balance impairment in older adults. The center of pressure (CoP) metrics are measured with a modified Wii Balance Board (mWBB) platform. In the intra- and inter-rater testing, 16 and 43 volunteers (mean 75.

Hybrid PWM Techniques for a DCM-232 Three-Phase Transformerless Inverter with Reduced Leakage Ground Current.

Pulse Width Modulation (PWM) strategies are crucial for controlling DC-AC power converters. In particular, transformerless inverters require specific PWM techniques to improve efficiency and to deal with leakage ground current issues. In this paper, three hybrid PWM methods are proposed for a DCM-232 three-phase topology.

A novel model to quantify balance alterations in older adults based on the center of pressure (CoP) measurements with a cross-sectional study.

Background: The timely detection of fall risk or balance impairment in older adults is transcendental because, based on a reliable diagnosis, clinical actions can be taken to prevent accidents. This study presents a statistical model to estimate the fall risk from the center of pressure (CoP) data.

Methods: This study is a cross-sectional analysis from a cohort of community-dwelling older adults aged 60 and over living in Mexico City.

A Trigger Phosphodiesterase Modulates the Global c-di-GMP Pool, Motility, and Biofilm Formation in Vibrio parahaemolyticus.

Vibrio parahaemolyticus cells transit from free-swimming to surface adapted lifestyles, such as swarming colonies and three-dimensional biofilms. These transitions are regulated by sensory modules and regulatory networks that involve the second messenger cyclic diguanylate monophosphate (c-di-GMP). In this work, we show that a previously uncharacterized c-di-GMP phosphodiesterase (VP1881) from V.

An expanded auxin-inducible degron toolkit for Caenorhabditis elegans.

The auxin-inducible degron (AID) system has emerged as a powerful tool to conditionally deplete proteins in a range of organisms and cell types. Here, we describe a toolkit to augment the use of the AID system in Caenorhabditis elegans. We have generated a set of single-copy, tissue-specific (germline, intestine, neuron, muscle, pharynx, hypodermis, seam cell, anchor cell) and pan-somatic TIR1-expressing strains carrying a co-expressed blue fluorescent reporter to enable use of both red and green channels in experiments.

Portable electronic device to assess the human balance using a minimum number of sensors.

Objective: This paper presents the design and development of a new electronic portable device to assess the human balance of the human body during standing, using a minimal number of sensors and peripheral components. This device is aimed to evaluate human balance in environments outside of specialized laboratories, such as small clinics and therapy offices.

Approach: The design is based on previous designs using three or more resistive force sensors attached to the feet, however in the present work, the sensors were attached on an adjustable platform, to fit several sizes of feet.

The conserved molting/circadian rhythm regulator NHR-23/NR1F1 serves as an essential co-regulator of spermatogenesis.

In sexually reproducing metazoans, spermatogenesis is the process by which uncommitted germ cells give rise to haploid sperm. Work in model systems has revealed mechanisms controlling commitment to the sperm fate, but how this fate is subsequently executed remains less clear. While studying the well-established role of the conserved nuclear hormone receptor transcription factor, NHR-23/NR1F1, in regulating molting, we discovered that NHR-23/NR1F1 is also constitutively expressed in developing primary spermatocytes and is a critical regulator of spermatogenesis.

Portable Device for the Measurement and Assessment of the Human Equilibrium.

This work presents the design and development of a new alternative tool to measure the Center of Pressure (CoP) displacements, intended to evaluate the human balance. The device is based on a modified commercial balance board used for video games, resulting in a low-cost, portable device capable of computing the CoP, providing 24 of the most used indexes to test the human balance. The proposed standalone device runs on rechargeable batteries, weighs only 3.

Towards an anxiety and stress recognition system for academic environments based on physiological features.

Background And Objective: Traditional methods to determine stress and anxiety in academic environments consist of the application of questionnaires, but the main disadvantage is that the results depend on the students' self-perception. Being able to detect anxiety-related stress levels in a simple and objective way contributes greatly to dealing with low performance and school drop-out by students.

Methods: The main contribution of this study is to identify the physiological features that could be used as predictors of stressful activities and states of anxiety in academic environments using an Arduino board and low-cost sensors.

Bilateral enucleation at birth modifies calcium spike amplitude, but not frequency, in neurons of the somatosensory thalamus and cortex: Implications for developmental cross-modal plasticity.

Bilateral eye enucleation at birth (BE) leads to an expansion of the primary somatosensory cortex (S1) in rat pups. Although increased growth of the somatosensory thalamo-cortical afferents (STCAs) in part explains S1 expansion, timing mechanisms governing S1 formation are also involved. In this work, we begin the search of a developmental clock by intending to document the existence of putative clock neurons in the somatosensory thalamus (VPM) and S1 based upon changes of spontaneous spike amplitude; a biophysical property sensitive to circadian regulation; the latter known to be shifted by enucleation.

Postural sway parameters using a triaxial accelerometer: comparing elderly and young healthy adults.

The purpose of this study was to evaluate the sensitivity of 16 parameters derived from acceleration to detect changes caused by age and visual conditions during quiet standing and detect and minimise possible sources of unwanted variability that could affect accelerometer measures on the trunk. Twenty-seven healthy subjects, including 16 elderly (age, 69.3 ± 3.

Detection of anticipatory postural adjustments prior to gait initiation using inertial wearable sensors.

Background: The present study was performed to evaluate and characterize the potential of accelerometers and angular velocity sensors to detect and assess anticipatory postural adjustments (APAs) generated by the first step at the beginning of the gait. This paper proposes an algorithm to automatically detect certain parameters of APAs using only inertial sensors.

Methods: Ten young healthy subjects participated in this study.

Valproic acid modulates brain plasticity through epigenetic chromatin remodeling in the blind rat: implications for human sight recovery.

Blindness is a pervasive sensory condition that imposes diverse difficulties to carry on with activities of daily living. In blind individuals, the brain is subjected to a large scale reorganization characterized by expanded cortical territories associated with somatosensory and auditory functions and the recruitment of the former visual areas to perform bimodal somatosensory and auditory integration. This poses obstacles to efforts aimed at reassigning visual functions to the recruited visual cortex in the blind, especially after the end of the ontogentic sensitive period.