Publications by authors named "Martinez-Losada C"
Acute myeloid leukemia (AML) is a heterogeneous disease classified into three risk categories (favorable, intermediate and adverse) with significant differences in outcomes. Definitions of risk categories evolve overtime, incorporating advances in molecular knowledge of AML. In this study, we analyzed the impacts of evolving risk classifications in 130 consecutive AML patients in a single-center real-life experience.
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- - The study examines genetic changes in relapsed adult acute lymphoblastic leukemia (ALL), finding a high degree of genetic diversity without a clear relapse pattern, despite new treatments.
- - Analysis of samples from 31 adult patients indicated a trend of acquiring specific genetic deletions and an increase in genetic alterations from diagnosis to relapse, particularly involving genes like CDKN2A/B and PAX5.
- - The findings suggest that while the genetics of relapsed ALL is complex and varied, targeting specific deregulated pathways could enhance the effectiveness of current therapies for relapse cases.
Donor natural killer (NK) cells can destroy residual leukemic cells after allogeneic hematopoietic stem cell transplantation. This effect is based on the interaction of killer-cell immunoglobulin-like receptors (KIR) of donor NK cells with ligands of the major histocompatibility complex found on the surface of the target cells. HLA-C1 subtypes provide the ligand for KIR2DL2 and KIR2DL3 and the HLA-C2 subtypes for KIR2DL1.
View Article and Find Full Text PDFChronic lymphocytic leukemia (CLL) is characterized by extremely variable clinical course indicating substantial differences in the biology of the disease. Molecular characterization provides new insights useful for treatment decision making. We report on a patient diagnosed with CLL, whose disease was characterized by episodes of rapid progression and disease stabilization, and in which a SRSF2 gene mutation was identified in the absence of other commonly known mutations of CLL.
View Article and Find Full Text PDFBackground And Objective: Acute myeloid leukemia (AML) is the most frequent type of acute leukemia in adults. Despite recent advances in the characterization of pathogenesis of AML, the cure rates are under 40%, being leukemia relapse the most common cause of treatment failure. Leukaemia relapse occurs due to clonal evolution or clonal escape.
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