Publications by authors named "Martinez-Fabregas E"
Article Synopsis
- A new type of immunosensor has been developed using biocomposite materials made from graphite powder, rabbit IgG, and resins, which serve both as a reservoir for biological molecules and a transducer.
- To evaluate its analytical capabilities, a competitive binding assay was created to measure the presence of rabbit IgG in a sample, utilizing goat anti-rabbit IgG labeled with an enzyme for detection.
- The immunosensor's surface can be easily regenerated through polishing, allowing for repeated use in subsequent assays.
Article Synopsis
- The study validates an automatic urea analyser that monitors crucial hemodialysis parameters like dialysis delivery (KT/V) and protein catabolism (PCRn).
- The analyser connects directly to the dialysis machine and processes urea concentration data in almost real time, using a specific mathematical model for calculation.
- Results from the new analyser closely matched traditional lab methods across 24 patient data sets, showing no significant differences in the KT/V and PCRn values.
On-line monitoring of urea in effluent liquid during haemodialysis.
J Pharm Biomed Anal
October 1993
Article Synopsis
- A specialized analytical system for real-time urea monitoring during haemodialysis is described, utilizing the dialyser's inflow as a continuous carrier solution.
- The system incorporates a bioreactor with immobilized urease and a gas-diffusion module, converting urea to ammonia gas for measurement by an ion-sensitive electrode.
- Validation of the on-line analyser was established through correlation with conventional spectrophotometric methods for measuring urea clearances, confirming its effectiveness in optimizing haemodialysis sessions.
Covalent binding of urease on ammonium-selective potentiometric membranes.
Biosens Bioelectron
April 1993
Article Synopsis
- The study focuses on developing disposable probes for measuring urea by covalently binding urease to ammonium-selective membranes.
- Two types of membranes were tested: type 1 used thin layers of cellulose acetate coated on PVC membranes, while type 2 used a blend of PVC and cellulose acetate.
- Type 1 membranes showed better performance, with a detection range for urea from 2 x 10(-5) to 0.01 M and a sensitivity of 50 mV/decade, compared to type 2 which was negatively affected by sodium periodate treatment.
A simply constructed, tubular, all-solid-state, flow-through silver electrode for flow-injection analysis (F.I.A.
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