Publications by authors named "Martinez-Brown J"

Article Synopsis
  • Rhabdosynochus viridisi is a monogenean parasite that infects the gills of Pacific white snook, impacting the aquaculture industry, yet its effects on the fish's immune response are not well understood.
  • The study used RNA sequencing to identify and analyze differentially expressed genes (DEGs) in infected fish, revealing 1430 DEGs, with a majority being downregulated, indicating potential inactivation of important immune pathways.
  • Notably, while pro-inflammatory cytokines showed no change, certain immune-related genes linked to Th17-like immunity were upregulated, suggesting a specific immune response to the parasitic infection.
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Article Synopsis
  • Protein kinases play crucial roles in various biological functions and are important drug targets, especially in humans.
  • This study focused on identifying and classifying kinases in two monogenean parasites that affect farmed fish, aiming to find potential drug targets.
  • Out of the identified kinases, 22 were classified as monogenean drug targets, with some existing drugs showing promise for repurposing against these parasites.
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Monogeneans are parasitic platyhelminths that can harm the health of farmed fish. Few treatments are available against monogeneans, and the incentive to develop new antiparasitic agents is similar or even lower than the incentive for neglected parasitic diseases in humans. Considering that searching for and developing new antimonogenean compounds may require enormous investments of time, money, and animal sacrifice, the use of a computer-guided drug repositioning approach is a reasonable alternative.

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Historically, the taxonomic identification of the two snook species, Centropomus viridis and C. nigrescens, has been challenging due to their morphological similarity and the inconsistency of the characters used for diagnosis. Therefore, this study aimed to evaluate the usefulness of the morphologic, meristic, and morphometric characters currently being used to identify C.

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Monogeneans are parasitic flatworms that may be a threat for finfish aquaculture. In this study, the anthelmintic activity of two terpenes, geraniol and β-citronellol, was tested in vitro against ancyrocephalin and diplectanid monogeneans. Experiments were performed in both water and a culture medium.

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The effects of feed deprivation were evaluated for 1 week and 2 weeks in Lutjanus guttatus juveniles. A significant reduction in body mass was observed in both feed deprivation schemes, as well as in hepatosomatic, viscerosomatic and mesenteric fat indexes. The composition of fasted fish was characterized by a decrease in lipid content; the liver displayed an intense reduction of lipid reserves in both fasted groups, and increased expression of the lysosomal acid lipase.

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To examine the pathogenicity of Vibrio strains, several doses of Vibrio harveyi (CAIM 1622 and CAIM 1508), Vibrio ponticus (CAIM 1751) and Vibrio anguillarum (CAIM 8) were used to challenge Pacific white snook Centropomus viridis Lockington, 1877 juveniles, and survival, gross signs and histological lesions were observed. Susceptibility of pathogenic vibrios CAIM 1508 and CAIM 1751 to antibiotics used in aquaculture was also evaluated. The growth ability of the tested strains was not related to their pathogenicity.

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The embryonic development of the bullseye puffer, Sphoeroides annulatus, was characterized on the basis of the theory of saltatory ontogeny. This theory predicts a correlative relationship between the ontogeny-type in an altricial-precocial spectrum and the habitat that a species occupies within an unstable-stable environmental spectrum. Because S.

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Little is known about the strategies for immunization and immunostimulation in marine fish larvae; however, both strategies have the potential to improve survival during the first days of larval culture. The biological variety of marine fish larvae complicates the standardization of the application of these strategies, although the mechanisms of early development are similar in marine species of commercial importance and those with aquaculture potential. Immunostimulation experiments performed with fish larvae provide evidence that helps to further understand the mechanisms of trained immunity, which can be used to understand responses to immunostimulation treatments.

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