An experimental model of chronic osteomyelitis caused by Escherichia coli treated with cefotaxime.

An experimental model in Wistar rats, of osteomyelitis caused by Escherichia coli, was used to evaluate the efficacy of cefotaxime in two treatment regimens of different durations. Four groups of rats were set up: a group of rats receiving short-term treatment (14 days) with subcutaneous cefotaxime (100 mg bd), killed after 56 days; a control group receiving no treatment, killed after 56 days; a group of rats undergoing long-term treatment (28 days) with subcutaneous cefotaxime as above, killed after 70 days and a control group of rats receiving no treatment, killed after 70 days. Analysis of histopathological and microbiological findings revealed significantly better results in the long-term treatment group.

Sex pheromone biosynthetic pathway in Spodoptera littoralis and its activation by a neurohormone.

Deuterium-labeled fatty acids have been used to elucidate the sex pheromone biosynthetic pathway in Spodoptera littoralis. Label from palmitic acid was incorporated during the scotophase into all the pheromone acetates and their corresponding fatty acyl intermediates. (Z,E)-9,11-tetradecadienyl acetate, the major component of the pheromone blend, is synthesized from palmitic acid via tetradecanoic acid, which, by the action of a specific (E)-11 desaturase and subsequently a (Z)-9 desaturase, is converted into (Z,E)-9,11-tetradecadienoate.

[Prevalence of peptic ulcer in smokers and non-smokers in Aragon].

The present study has attempted to determine the prevalence of peptic ulcer (UP) in smokers and nonsmokers in the geographic region of Aragon (Spain) using a sample of 10,000 subjects, 1,897 with ulcer, 1,708 of them diagnosed by endoscopy. The prevalence of smokers is 42.4% (63% of males and 14% of females).

Progesterone increases glomerular filtration rate, urinary kallikrein excretion and uric acid clearance in normal women.

In pregnancy there is a rise in glomerular filtration rate (GFR), plasma aldosterone levels, uric acid clearance and urinary kallikrein excretion. In toxemia all the above parameters tend to decrease. Progesterone has a diuretic effect which is usually related to aldosterone antagonism.

Removal of cactus spines from the skin. A comparative evaluation of several methods.

The removal of very fine cactus spines from the skin is particularly distressing for the pediatric patient. We describe two typical patients and a study in experimental animals comparing the effectiveness of several previously described methods for removal. The most effective method involved using tweezers to remove clumps of spines followed by a thin layer of glue covered with gauze, which was allowed to dry and then peeled off to remove individual spines.

The effects of glucose on myocardial substrate utilization in acute myocardial infarction or angina pectoris.

Infusion of glucose-insulin-potassium during acute myocardial infarction has favorable clinical and hemodynamic effects, presumably as a result of decreased myocardial utilization of free fatty acids. In 14 patients with coronary artery disease, hypertonic glucose (a bolus of 10 g followed by infusion of a 30% glucose solution at a constant rate of 10 mg/kg/min) was infused and arterial and coronary sinus levels of glucose, lactate and free fatty acids were measured before and after 15 and 30 minutes of infusion. Arterial glucose and lactate levels increased significantly after glucose infusion, whereas free fatty acid levels decreased significantly.

A comparison of the absorption and metabolism of isopropyl alcohol by oral, dermal and inhalation routes.

The admission of a child with an almost lethal level of isopropyl (alcohol 380 mg/dl) after sponge bathing for fever, and questionable ingestion, prompted the present experiment in animals. Twelve rabbits (2-2.6 kg) were divided into 4 groups of 3 each.