Publications by authors named "Martine Maugetfaysse"
Article Synopsis
- This study investigated eye and small blood vessel issues in patients who experienced symptoms after recovering from COVID-19, analyzing 44 patients mostly around 47 years old.
- Using advanced imaging techniques, researchers found significant retinal abnormalities, including hyperreflective dots and areas of capillary non-perfusion, indicating compromised blood flow.
- The results suggest that these retinal changes are linked to reduced capillary density, highlighting the importance of microvascular damage instead of just lasting problems with a protective layer around blood vessels.
Article Synopsis
- - The study investigates the link between early reperfusion (ER) and visual outcomes in patients with central retinal artery occlusion (CRAO) or branch retinal artery occlusion (BRAO), finding that ER occurs in nearly 50% of cases.
- - Researchers included 70 patients, mostly with CRAO, and assessed visual outcomes at one month, revealing that those with ER had better visual acuity and quality of life compared to those without it.
- - The findings suggest that therapies aimed at enhancing ER could significantly improve clinical outcomes for patients suffering from CRAO or BRAO.
Article Synopsis
- * Parkinson's disease (PD) patients treated with l-DOPA show some protection against nAMD, but the exact mechanism was unclear until now.
- * Research indicates that l-DOPA enhances dopamine receptor D2 (DRD2) signaling, which may inhibit the harmful growth of blood vessels in the eye, suggesting that DRD2 agonists could be potential complementary treatments for nAMD.
Purpose: To determine the loss of follow-up ratio and reasons during the COVID-19 lockdown in patients with retinal diseases treated by anti-vascular endothelial growth factor intravitreal injections and to report the visual outcome and rate of complications of these patients 1 year after the end of the lockdown.
Methods: This is a prospective descriptive cohort study (NCT04395859) conducted at the Rothschild Foundation Hospital - Paris between April 2020 and May 2021. Patients with retinal diseases treated by repeated intravitreal anti-VEGF injections (IVI) since before October 2019 were included.
Purpose: To determine the prevalence and characteristics of foveal hypoplasia (also called fovea plana) in patients with Best disease using spectral-domain (SD) optical coherence tomography (OCT) and OCT-angiography (OCT-A).
Design: A retrospective observational study including patients diagnosed with Best disease.
Subjects And Participants: Fifty-nine eyes of thirty-two patients (fifteen females (46.
Introduction: The performance of "en face" optical coherence tomography (OCT) in screening for chloroquine (CQ) or hydroxychloroquine (HCQ) retinopathy has not been largely explored. The aim of this study was to determine the concordance of "en face" OCT with multifocal electroretinography (mfERG) in screening for CQ/HCQ retinopathy.
Methods: This is a prospective cohort study conducted at the Rothschild Foundation Hospital, Paris, between August 2016 and February 2021.
Article Synopsis
- The study aimed to compare primary and secondary forms of multiple evanescent white dot syndrome (MEWDS) at baseline and after 1-4 months from symptom onset.
- A total of 101 eyes from 100 patients were analyzed; secondary MEWDS was linked to existing chorioretinal inflammatory conditions, making affected patients generally older.
- Findings showed that lesions in secondary MEWDS were smaller and less symmetrical, and there was more observable inflammation in imaging during recovery, suggesting chorioretinal inflammation may initiate secondary MEWDS.
Background And Purpose: This study was undertaken to determine the role of optical coherence tomography (OCT) in predicting the final visual and structural outcome, and to evaluate the correlation between functional eye outcome and retinal changes, in patients with a first episode of optic neuritis (ON).
Methods: In this prospective study, consecutive adult patients with acute ON underwent ophthalmological evaluation at baseline and at 1 and 12 months, including OCT measurements of peripapillary retinal nerve fiber layer (pRNFL), macular ganglion cell and inner plexiform layer, and inner nuclear layer thicknesses; high- and low-contrast visual acuity; visual field assessment; and baseline brain magnetic resonance imaging. Univariate and multivariate linear regressions were used to assess predictive factors of outcome.
Wilson's disease (WD) is an autosomal recessive genetic disorder due to a mutation of the ATP7B gene, resulting in impaired hepatic copper excretion and accumulation in various tissues. Ocular findings are one of the hallmarks of the disease. Many ophthalmological manifestations have been described and new techniques are currently available to improve their diagnosis and to follow their evolution.
View Article and Find Full Text PDFPurpose: The aim of this study is to compare the one year outcome of neovascular age-related macular degeneration (nAMD) patients treated by a PRN regimen of Anti-vascular endothelial growth factor (VEGF) intravitreal injections (IVTs), using optical coherence tomography B-scan (OCT-B) or OCT Angiography (OCT-A) imaging modalities during follow-up.
Methods: Patients older than 50 years with nAMD currently treated by PRN regimen of Anti-VEGF IVTs were recruited from Rothschild Foundation Hospital - Paris and Centre Ophtalmologique Maison Rouge - Strasbourg and followed-up for a year. Patients were randomized in two groups: one group was followed by OCT-B while the other was followed by OCT-A.
Purpose: To examine choroidal neovascularization (CNV) characteristics in patients with exudative age-related macular degeneration (AMD) and polypoidal choroidal vasculopathy (PCV), using swept-source optical coherence tomography angiography (SS-OCTA), and investigate agreement with OCT B-scan, fundus fluorescein angiography (FFA), and indocyanine green angiography (ICGA) by two different examiners.
Methods: This is a retrospective multicentric study that involved patients with a history of AMD and PCV. , who had access to OCTA, B-scan OCT, FFA, and ICGA imaging, had to differentiate between AMD and PCV, study the activity of AMD using Coscas' criteria (active vs.
Background: Acute macular neuroretinopathy (AMN) is an increasingly diagnosed disorder associated with several diseases. The aim of this study was to report the incidence of AMN cases diagnosed during the 2020 coronavirus disease 2019 (COVID-19) pandemic year in a French hospital, and to describe their different forms.
Methods: All patients diagnosed between 2019 and 2020, in Paris Rothschild Foundation Hospital, with AMN, paracentral acute middle maculopathy (PAMM) and multiple evanescent white dot syndrome (MEWDS) were retrospectively collected using the software Ophtalmoquery (Corilus, V1.
Purpose: To report the occurrence of paracentral acute middle maculopathy (PAMM) in giant cell arteritis (GCA), describe its features and outcomes, and identify risk factors associated with PAMM in patients with GCA.
Methods: Review of medical records of patients with GCA who were examined in the Rothschild Foundation Hospital. Patients were divided into three groups: GCA with PAMM (Group 1), GCA with ophthalmic involvement but without PAMM (Group 2), and GCA without ophthalmic involvement (Group 3).
The aim of the study is to report on the indocyanine green angiography (ICGA) and OCT findings in patients hospitalized for severe COVID infection. In this observational prospective monocentric cohort study, we included patients hospitalized for severe COVID infection. The main outcomes were ICGA and OCT findings.
View Article and Find Full Text PDFIn central serous chorioretinopathy (CSC), the macula is detached because of fluid leakage at the level of the retinal pigment epithelium. The fluid appears to originate from choroidal vascular hyperpermeability, but the etiology for the fluid is controversial. The choroidal vascular findings as elucidated by recent optical coherence tomography (OCT) and wide-field indocyanine green (ICG) angiographic evaluation show eyes with CSC have many of the same venous patterns that are found in eyes following occlusion of the vortex veins or carotid cavernous sinus fistulas (CCSF).
View Article and Find Full Text PDFArticle Synopsis
- This study investigates how the consumption of Red Bull (which contains taurine and caffeine) affects choroidal thickness in healthy volunteers.
- Using advanced imaging techniques, researchers measured the subfoveal choroidal thickness before and after drinking Red Bull.
- Results showed a significant temporary decrease in choroidal thickness 1 hour after drinking, especially in individuals with initially thicker choroids, with measurements returning to baseline by 4 hours.
Objectives: To collect information about the retinal blood flow variations and other choroidal and retinal parameters during a prolonged effort such as marathon running.
Design: Non-randomized prospective cohort study.
Methods: Patients were recruited through an information campaign at the Rothschild Foundation Hospital (Paris, France).
Purpose: To assess early changes in spectral-domain optical coherence tomography during the loading phase with intravitreal aflibercept therapy in patients with neovascular age-related macular degeneration.
Methods: In this prospective, open-label, single-arm, multicenter study, patients with neovascular age-related macular degeneration, who were antivascular endothelial growth factor treatment-naïve, received three monthly initial doses of intravitreal aflibercept 2 mg. The primary outcome was the proportion of patients with dry spectral-domain optical coherence tomography at 12 weeks, defined as an absence of intraretinal edema, intraretinal cysts, subretinal fluid, and subretinal pigment epithelium fluid.
Purpose: Numerous small hyperreflective dots (HRDs) can be seen within the hyporeflective layer between the ellipsoid zone (EZ) and the interdigitation zone (IZ) on C-scan spectral-domain optical coherence tomography (SD-OCT) with a yet unknown variation under light conditions. The aim of this study was to explore light-induced SD-OCT changes in these HRDs.
Methods: The study subjects were randomly assigned to two groups: Group 1 experienced a dark adaptation protocol followed by intense retinal photobleaching, while Group 2, serving as the control group, was exposed to constant ambient light without any variation.
Central retinal vein occlusion (CRVO) is a common retinal disease. Recent works mentioned spontaneous retinal arterial pulsations (SRAPs) as a feature of some CRVOs. This is a retrospective study on patients presenting with CRVO who were followed up for at least 6 months.
View Article and Find Full Text PDFPurpose: To highlight the advantages of optical coherence tomography angiography (OCTA) in delineating the morphological features of the retinal and choroidal vascular network during acute, relapsing, and quiescent stages of macular toxoplasma retinochoroiditis.
Methods: This prospective study included patients presenting with both active and quiescent ocular toxoplasmoses. OCTA was obtained to diagnose and follow the subsequent vascular network changes at diagnosis and six months after acute presentation.
Visual Recovery with Iloprost Added to Corticosteroids in a Case of Giant Cell Arteritis.
Ocul Immunol Inflamm
February 2022
Introduction: To date, corticosteroids remain the cornerstone treatment of ocular involvement of GCA, and no other treatment has proven to be effective in this setting. We herein report on a unique case of GCA with ocular involvement worsening despite high dose corticosteroids and recovering with intravenous iloprost.
Case Report: A 70-year-old man presented with acute vision loss in his left eye related to anterior ischemic optic neuropathy.
Background: This paper reports the case of a young man who presented with syphilis masquerading as multiple evanescent white dots syndrome (MEWDS), which turned out to be an acute syphilitic posterior placoid chorioretinopathy (ASPPC) during follow-up.
Case Presentation: A 59-year-old healthy male consulted for a three days' history of visual impairment in both eyes. On multimodal imaging, he was diagnosed as MEWDS.