Publications by authors named "Martine M C de Vries-Velraeds"
Cohort profile: the 'Biomarkers of heterogeneity in type 1 diabetes' study-a national prospective cohort study of clinical and metabolic phenotyping of individuals with long-standing type 1 diabetes in the Netherlands.
Henk-Jan Aanstoot Rita D M Varkevisser Dick Mul Pim Dekker Erwin Birnie Martine M C de Vries-Velraeds
BMJ Open
June 2024
Article Synopsis
- * The study involved a prospective cohort of 611 participants aged 16 and older with at least 5 years of T1D, plus a second group of 160 participants with a minimum of 35 years of T1D, gathering a range of health data, physical assessments, and biological samples.
- * Preliminary findings indicate that additional C-peptide secretion was noted in 10% of individuals, linking fasting C-peptide levels with reduced hypoglycemia awareness
Article Synopsis
- The study evaluated how stable C-peptide levels are over time in individuals with long-standing type 1 diabetes, focusing on both fasting C-peptide and responses after a mixed-meal tolerance test (MMTT).
- Among 607 participants, only 25% showed detectable fasting C-peptide, with levels significantly decreasing over one year, and patients with higher levels were generally diagnosed at an older age and had shorter disease duration.
- The findings indicated that stimulated C-peptide was found in 10% more participants during MMTT compared to fasting tests, and results from MMTT at 90 and 120 minutes closely matched overall C-peptide area under the curve measurements.
Article Synopsis
- The study investigated the link between fasting serum C-peptide levels and impaired awareness of hypoglycemia (IAH) in individuals with type 1 diabetes, involving data from 509 patients.
- 25% of participants showed residual C-peptide secretion, and 15% reported IAH; lower severe hypoglycemia was noted in those with C-peptide presence.
- The analysis indicated that higher age, longer diabetes duration, and various complications increased the risk of IAH, while residual C-peptide was linked to a lower prevalence of it.