Publications by authors named "Martine Lebrasseur"
Article Synopsis
- Distributed computations enable efficient multi-institutional data analysis without the complications of data pooling, but existing methods lack essential features such as medical standards, user-friendly data visualizations, and privacy controls.
- The Collaborative Data Analysis (CODA) platform was developed to address these gaps, successfully implementing multi-modal federated learning using a public dataset across multiple Canadian hospitals, with open-source code released for broader use.
- By January 2023, CODA was deployed in 8 out of 9 hospitals and enrolled over 1 million patients; however, mapping data from outdated systems posed significant challenges, with future improvements planned for enhanced risk assessment and data migration tools.
Article Synopsis
- This study examined the effects of intravenous vitamin C on adults with sepsis in the ICU, comparing its impact to a placebo.
- Among 872 patients, those receiving vitamin C had a higher combined risk of death or persistent organ dysfunction at 28 days compared to the control group.
- The results indicated no significant improvement in outcomes for organ dysfunction, survival, or quality of life, leading to the conclusion that vitamin C may not be beneficial in this patient population.
The evolution of mean arterial pressure in critically ill patients on vasopressors before and during a trial comparing a specific mean arterial pressure target to usual care.
BMC Anesthesiol
January 2022
Background: In randomized clinical controlled trials, the choice of usual care as the comparator may be associated with better clinician uptake of the study protocol and lead to more generalizable results. However, if care processes evolve to resemble the intervention during the course of a trial, differences between the intervention group and usual care control group may narrow. We evaluated the effect on mean arterial pressure of an unblinded trial comparing a lower mean arterial pressure target to reduce vasopressor exposure, vs.
View Article and Find Full Text PDFIntroduction: Vasodilatory hypotension is common among intensive care unit (ICU) patients; vasopressors are considered standard of care. However, optimal mean arterial pressure (MAP) targets for vasopressor titration are unknown. The objective of the Optimal VAsopressor TitraTION in patients 65 years and older (OVATION-65) trial is to ascertain the effect of permissive hypotension (vasopressor titration to achieve MAP 60-65 mm Hg) versus usual care on biomarkers of organ injury in hypotensive patients aged ≥65 years.
View Article and Find Full Text PDFBackground: Sepsis is a health problem of global importance; treatments focus on controlling infection and supporting failing organs. Recent clinical research suggests that intravenous vitamin C may decrease mortality in sepsis. We have designed a randomized controlled trial (RCT) to ascertain the effect of vitamin C on the composite endpoint of death or persistent organ dysfunction at 28 days in patients with sepsis.
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