Publications by authors named "Martine Grall Lerosey"
Article Synopsis
- The study investigates the use of weekly adalimumab in children suffering from non-infectious chronic anterior uveitis (CAU), which is often difficult to treat.
- Out of 42 children with CAU, 64.3% were treated with adalimumab, and 40.7% of those required an increase to weekly doses, achieving inflammation control in 63.6% of cases after 3 and 6 months.
- The findings suggest that weekly adalimumab is effective and safe for managing CAU in children, paving the way for it to be considered before switching to other biologic treatments, although more controlled studies are recommended.
The purpose of the study is to highlight clinical signs that are either suggestive of or against the diagnosis of AHEI to improve diagnosis and management. The medical records of children under 3 years old diagnosed with AHEI were retrospectively reviewed. Clinical data and photographs were reviewed by three independent experts, and the cases were classified as probable, doubtful, or unclear AHEI.
View Article and Find Full Text PDFObjective: To identify the molecular basis of a severe systemic autoinflammatory disorder (SAID) and define its main phenotypic features, and to functionally assess the sequence variations identified in LYN, a gene encoding a nonreceptor tyrosine kinase.
Methods: We used targeted next-generation sequencing and in vitro functional studies of Lyn phosphorylation state and Lyn-dependent NF-κB activity after expression of recombinant Lyn isoforms carrying different sequence variations.
Results: We identified a de novo LYN variation (p.
Objective: To evaluate the demographics, aetiologies, complications, treatments and visual prognoses of chronic and recurrent non-infectious paediatric-onset uveitis in France.
Methods: Descriptive, retrospective and bicentric study in patients whose disease started before 17 and who were followed up in two centres from January 2010 to May 2017.
Results: We included 147 patients with 268 affected eyes.
Methotrexate has demonstrated its efficiency for the treatment of juvenile localized scleroderma but some patients may be resistant. The aim of our study was to define the profile of such patients. We performed an observational retrospective multicenter study between 2007 and 2016 and included all children seen in the French Paediatric Dermatology and Rheumatology departments with active localized scleroderma treated by methotrexate for a minimum of 4 months.
View Article and Find Full Text PDFObjective: To determine the type and frequency of musculoskeletal symptoms at onset and during followup of cryopyrin-associated periodic syndromes (CAPS).
Methods: We retrospectively recorded the articular and muscular symptoms of patients with CAPS followed up in French hospitals. Data were presented as frequencies or the median (range), and patient groups were compared using chi-square test, Fisher's exact test, and Mann-Whitney test.