Publications by Martine Annemarie Boks

Publications by authors named "Martine Annemarie Boks"

Page 1 of 1

Glycan modification of antigen alters its intracellular routing in dendritic cells, promoting priming of T cells.

Ingeborg Streng-Ouwehand Nataschja I Ho Manja Litjens Hakan Kalay Martine Annemarie Boks

Elife

March 2016

Antigen uptake by dendritic cells and intracellular routing of antigens to specific compartments is regulated by C-type lectin receptors that recognize glycan structures. We show that the modification of Ovalbumin (OVA) with the glycan-structure Lewis(X) (Le(X)) re-directs OVA to the C-type lectin receptor MGL1. Le(X)-modification of OVA favored Th1 skewing of CD4(+) T cells and enhanced cross-priming of CD8(+) T cells.

View Article and Find Full Text PDF

- Martine Annemarie Boks focuses on the mechanisms of antigen processing and presentation by dendritic cells, particularly how glycan modifications influence these processes.
- Her research highlights that the glycan structure Lewis(X) (Le(X)) alters the intracellular routing of antigens, specifically Ovalbumin (OVA), by directing them to the C-type lectin receptor MGL1.
- The findings indicate that Le(X)-modification enhances the skewing of CD4(+) T cells towards a Th1 response and improves the cross-priming of CD8(+) T cells, which has implications for developing more effective vaccines.

Publications by authors named "Martine Annemarie Boks"

Glycan modification of antigen alters its intracellular routing in dendritic cells, promoting priming of T cells.

Synopsis of recent research by authors named "Martine Annemarie Boks"