An oncolytic HSV-1 vector induces a therapeutic adaptive immune response against glioblastoma.

Background: Glioblastoma (GBM) is the most frequent and aggressive brain tumor in adults with the lowest survival rates five years post-diagnosis. Oncolytic viruses (OVs) selectively target and damage cancer cells, and for this reason they are being investigated as new therapeutic tools also against GBM.

Methods: An oncolytic herpes simplex virus type 1 (oHSV-1) with deletions in the γ34.

Pain perception and physiological responses are modulated by active support from a romantic partner.

As social animals, humans are strongly affected by social bonds and interpersonal interactions. Proximity and social support from significant others may buffer the negative outcomes of a painful experience. Several studies have investigated the role of romantic partners' support in pain modulation, mostly focusing on tactile support and showing its effectiveness in reducing pain perception.