Publications by authors named "Martina Vetro"
Article Synopsis
- Asparaginase (ASNase) significantly improves treatment outcomes for pediatric Acute Lymphoblastic Leukemia (ALL), achieving remissions in about 90% of cases, but its effects on adult solid tumors are not well understood.
- In a study on three adenocarcinoma cell lines (A549, MCF-7, and 786-O), it was found that A549 and 786-O cells responded differently to ASNase treatment, with A549 showing a typical response while 786-O displayed alterations in cell cycle phases and dysfunctional DNA synthesis.
- The findings suggest unique mechanisms of ASNase action in solid tumors, particularly in the 786-O cells, indicating a different response than what is seen in leukemic
Background: DNA-Damaged Binding protein 2 (DDB2) is a protein involved in the early step of Nucleotide Excision Repair. Recently, it has been reported that DDB2 is involved in epithelial-to-mesenchymal transition (EMT), key process in tumour invasiveness and metastasis formation. However, its role is not completely known.
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