Publications by authors named "Martina Selina Ninck"
Article Synopsis
- Adult-type diffuse gliomas, particularly those classified as CNS WHO grade 4, are highly aggressive brain tumors that pose significant challenges for treatment; this study analyzed their genetic and molecular changes after recurrence.
- The research involved sequencing and profiling to uncover alterations in recurrent gliomas, revealing that 75% of patients had early branching evolution, along with changes in mutational patterns and increased TGF-β signaling.
- Findings indicate that TGF-β plays a critical role in the recurrence of gliomas and could guide future therapies, particularly with TGF-β inhibitors potentially aiding in overcoming resistance to chemoradiation treatments.
