Publications by authors named "Martina Schaumburg"
Objective: We examine the trajectories of and the dynamic interplay between cognitive functioning and depressive symptoms in patients with Parkinson's disease (PD) in comparison to healthy controls (HC) from an intraindividual perspective.
Method: The DeNoPa study is a single-center, observational, longitudinal study with biennial follow-ups over 8 years. The present analyses are based on 123 PD (79 male) and 107 HC (64 male) with a mean age of 64.
Article Synopsis
- The study aimed to assess the progression rate of motor and cognitive symptoms in early Parkinson's disease (PD) compared to healthy controls, as well as to identify baseline predictors for this progression.
- Involving 135 new PD patients and 109 healthy controls, the research utilized specific rating scales (MDS-UPDRS III for motor symptoms and MMSE for cognitive symptoms) over a 4-year period to analyze changes.
- Results highlighted that symptoms in PD worsened, with identifiable baseline factors (like male sex and hypertension) predicting faster motor progression, while cognitive decline was linked to factors like heavy alcohol use and diabetes, indicating cardiovascular and metabolic influences on disease progression.
Objective: This was a longitudinal single-center cohort study to comprehensively explore multimodal progression markers for Parkinson disease (PD) in patients with recently diagnosed PD (n = 123) and age-matched, neurologically healthy controls (HC; n = 106).
Methods: Thirty tests at baseline and after 24 months covered nonmotor symptoms (NMS), cognitive function, and REM sleep behavior disorder (RBD) by polysomnography (PSG), voxel-based morphometry (VBM) of the brain by MRI, and CSF markers. Linear mixed-effect models were used to estimate differences of rates of change and to provide standardized effect sizes (d) with 95% confidence intervals (CI).
Introduction: Harmonizing data across cohorts is important for validating findings or combining data in meta-analyses. We replicate and validate a previous conversion of MoCA to MMSE in PD.
Methods: We used five studies with 1,161 PD individuals and 2,091 observations measured with both the MoCA and MMSE.
Objective: To determine nonmotor signs (NMS) and evaluate the utility of several diagnostic tools in patients with de novo Parkinson disease (PD).
Methods: This is a large single-center study of the DeNoPa cohort, including frequency-matched healthy controls. This study covers motor signs, NMS, and a combination of diagnostic tests including olfactory testing, transcranial sonography of substantia nigra (TCS), and polysomnography (PSG).