TypA is involved in virulence, antimicrobial resistance and biofilm formation in Pseudomonas aeruginosa.

Background: Pseudomonas aeruginosa is an important opportunistic human pathogen and is extremely difficult to treat due to its high intrinsic and adaptive antibiotic resistance, ability to form biofilms in chronic infections and broad arsenal of virulence factors, which are finely regulated. TypA is a GTPase that has recently been identified to modulate virulence in enteric Gram-negative pathogens.

Results: Here, we demonstrate that mutation of typA in P.