Publications by authors named "Martina Quagliata"
Article Synopsis
- Humans face potential health risks from mycotoxins in their diet, but most risk assessments don't consider the effects of exposure to multiple mycotoxins at once.
- This study examined the combined toxic effects of three specific mycotoxins—sterigmatocystin, ochratoxin A, and patulin—on human neuroblastoma and healthy mesenchymal stem cells using advanced 3D cell cultures.
- Findings showed that exposures to these mycotoxins together increased their toxic effects compared to individual exposures, emphasizing the need for better regulatory measures that address mycotoxin mixtures in food.
Mycotoxins are secondary metabolites produced by filamentous fungi associated with a variety of acute and chronic foodborne diseases. Current toxicology studies mainly rely on monolayer cell cultures and animal models, which are undeniably affected by several limitations. To bridge the gap between the current in vitro toxicology approach and the in vivo predictability of the data, we here investigated the cytotoxic effects induced by the mycotoxins sterigmatocystin (STE), ochratoxin A (OTA) and patulin (PAT) on different 2D and 3D cell cultures.
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