Lean people with dysglycemia have a worse metabolic profile than centrally obese people without dysglycemia.

Aim: This study compared metabolic profiles of Asian Indians with normal waist circumference (WC) and dysglycemia versus those with high WC without dysglycemia.

Subjects And Methods: In 2,350 subjects ≥20 years of age from the Chennai Urban Rural Epidemiology Study with full anthropometric and biochemical characterization, high WC was defined as ≥90 cm in males and ≥80 cm in females. Dysglycemia was defined as prediabetes (fasting plasma glucose ≥100 mg/dL and/or 2-h plasma glucose ≥140 mg/dL) or diabetes (fasting plasma glucose ≥126 mg/dL, 2-h plasma glucose ≥200 mg/dL, or treatment for diagnosed diabetes).