Publications by authors named "Martina M Golden"
Article Synopsis
- By 2050, bacterial infections are projected to result in 1.8 million more deaths annually compared to cancer, highlighting a severe antibiotic discovery crisis.
- Gram-negative bacteria are particularly concerning due to their multi-drug resistance from their thick outer membrane.
- This review explores a new strategy to combat bacterial pathogenicity by disrupting metal homeostasis, improving antibiotic effectiveness, and discusses the limited success of metallophores in clinical trials.
Antibacterial resistance poses a severe threat to public health; an anticipated 14-fold increase in multidrug-resistant (MDR) bacterial infections is expected to occur by 2050. Contrary to antibiotics, combination therapies are the standard of care for antiviral and anticancer treatments, as synergistic drug-drug interactions can decrease dosage and resistance development. In this study, we investigated combination treatments of a novel succinate dehydrogenase inhibitor (promysalin) with specific inhibitors of metabolism and efflux alongside a panel of clinically approved antibiotics in synergy studies.
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