Publications by authors named "Martina M Braun"
Article Synopsis
- Epigenetic heterogeneity plays a key role in how biological systems function and can influence tumor behavior and resistance to treatments.
- The authors introduce a new tool called epiCHAOS, which measures variations in epigenetic traits between individual cells, regardless of their grouping.
- After testing its effectiveness on simulated data, epiCHAOS is shown to reveal important insights into developmental and cancer-related characteristics, enhancing our understanding of single-cell epigenomics in these contexts.
Single-cell bisulfite sequencing (scBS) is a technique that enables the assessment of DNA methylation at single-base pair and single-cell resolution. The analysis of large datasets obtained from scBS requires preprocessing to reduce the data size, improve the signal-to-noise ratio and provide interpretability. Typically, this is achieved by dividing the genome into large tiles and averaging the methylation signals within each tile.
View Article and Find Full Text PDF