Exhalative Breath Markers Do Not Offer for Diagnosis of Interstitial Lung Diseases: Data from the European IPF Registry (eurIPFreg) and Biobank.

: New biomarkers are urgently needed to facilitate diagnosis in Interstitial Lung Diseases (ILD), thus reducing the need for invasive procedures, and to enable tailoring and monitoring of medical treatment. In this study we investigated if patients with idiopathic pulmonary fibrosis (IPF; = 21), non-IPF ILDs ( = 57) and other lung diseases (chronic obstructive pulmonary disease (COPD) = 24, lung cancer (LC) = 16) as well as healthy subjects ( = 20) show relevant differences in exhaled NO (FeNO; Niox MINO), or in eicosanoid (PGE2, 8-isoprostane; enzyme-linked immunosorbent assay (ELISA)) levels as measured in exhaled breath condensates (EBC) and bronchoalveolar lavage fluids (BALF). There was no significant difference in FeNO values between IPF, non-IPF ILDs and healthy subjects, although some individual patients showed highly elevated FeNO.

Diagnostic benefits of presurgical fMRI in patients with brain tumours in the primary sensorimotor cortex.

Objectives: Reliable imaging of eloquent tumour-adjacent brain areas is necessary for planning function-preserving neurosurgery. This study evaluates the potential diagnostic benefits of presurgical functional magnetic resonance imaging (fMRI) in comparison to a detailed analysis of morphological MRI data.

Methods: Standardised preoperative functional and structural neuroimaging was performed on 77 patients with rolandic mass lesions at 1.