Exploring the impact of mobility restrictions on the COVID-19 spreading through an agent-based approach.

Background: The recent health emergency caused by the COVID-19 pandemic forced people to change their mobility habits, with the reduction of non-essential travels and the promotion online activities. During the first phase of the emergency in 2020, governments considered several mobility restrictions to avoid the pandemic diffusion. However, it is difficult to quantify the actual effects of these restrictions on the virus spreading, especially due to the biased data available.

Risk of venous and arterial thromboembolic events in women with advanced breast cancer treated with CDK 4/6 inhibitors: A systematic review and meta-analysis.

Background: Cyclin-dependent kinase inhibitors (CDKIs) may increase the risk of thrombotic events of endocrine therapy (ET) in women with hormone-sensitive, HER2-negative advanced breast cancer (BC). Aim of our systematic review is the estimate of the risk of venous and arterial thromboembolism in women with advanced BC treated with CDKIs in phase III randomized controlled trials (RCTs).

Methods: Studies were identified by electronic search of MEDLINE, EMBASE and CENTRAL database until October 2021.