Publications by authors named "Martina Di Giuseppe"

Invasive infections caused by (iGAS), commonly known as Group A Streptococcus, represent a significant public health concern due to their potential for rapid progression and life-threatening complications. Epidemiologically, invasive GAS infections exhibit a diverse global distribution, affecting individuals of all ages with varying predisposing factors. The pathogenesis of invasive GAS involves an array of virulence factors that contribute to tissue invasion, immune evasion, and systemic dissemination.

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Background: Despite its broad spectrum and excellent safety profile, fosfomycin is still rarely used in pediatrics, with very limited experience from clinicians.

Methods: We retrospectively reviewed the medical records of all children admitted to Bambino Gesù Children's Hospital, IRCCS, Rome, Italy, and treated with fosfomycin for any serious infection. Children with immunodeficiency and oncologic diseases were excluded.

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Aim: Higher number of monocytes and neutrophils may correlate with active tuberculosis (TB) in children. However, the few paediatric studies available are limited by the small numbers of children with TB disease or infection included.

Methods: We calculated the monocyte-to-lymphocyte-ratio (MLR), neutrophil-to-lymphocyte-ratio (NLR) and neutrophil-to-monocyte-plus-lymphocyte-ratio (NMLR) in children with active TB, latent TB infection (LTBI), other infectious and non-infectious conditions and healthy children evaluated in two referral centres in Rome.

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Article Synopsis
  • COVID-19 and tuberculosis (TB) are significant causes of death among infectious diseases, with a potential link between active TB and increased COVID-19 risk, particularly in children.
  • Three cases of pediatric COVID-TB are reported, including a 5-year-old with mild symptoms, a 13-year-old needing COVID-19 treatment, and a 10-year-old with severe TB but no COVID-19 complications.
  • The findings suggest that children with COVID-TB may face worse health outcomes, highlighting the need for careful monitoring and targeted COVID-19 treatments in pediatric cases.
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Background: The spread of carbapenem-resistant organisms (CROs) is an increasingly serious threat globally, especially in vulnerable populations, such as intensive care unit (ICU) patients. Currently, the antibiotic options for CROs are very limited, particularly in pediatric settings. We describe a cohort of pediatric patients affected by CRO infections, highlighting the important changes in carbapenemase production in recent years and comparing the treatment with novel cephalosporins (N-CEFs) to Colistin-based regimens (COLI).

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While there are numerous studies regarding infection (CDI) in adults, literature on the pediatric population is scarce. Therefore, we performed a 5-year retrospective study between January 2014 and December 2018 in two referral centers in Rome, Italy. There were 359 patients tested for CDI who were enrolled: 87 resulted in positive and 272 in negative.

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Monoclonal antibody therapies for COVID-19 have been frequently used in adults, whereas there are little data regarding the safety or efficacy of monoclonal antibody treatments in pediatric patients affected by COVID-19. We report our experience in the administration of mAb as a treatment for SARS-CoV-2 infection in children aged from 24 days to 18 years old.

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Article Synopsis
  • SARS-CoV-2 infection in children is usually mild and typically doesn’t require long hospital stays, but managing these cases can present social challenges.
  • A study at Bambino Gesù Pediatric Hospital involved monitoring 65 discharged children with positive COVID-19 tests through a telephonic follow-up to track symptoms and ensure recovery.
  • The follow-up revealed that most patients experienced mild symptoms, while two required re-hospitalization due to serious conditions, suggesting that remote monitoring can safely facilitate early discharge and prompt treatment for complications.
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