Publications by authors named "Martina C Murphy"
Article Synopsis
- BAP1 mutations lead to a loss of function affecting cell cycle and DNA repair, making patients potentially responsive to PARP inhibitors like niraparib.
- A phase II trial evaluated niraparib in patients with advanced tumors likely to have mBAP1 mutations, focusing on response rates, progression-free survival, and overall survival.
- Despite not meeting the primary efficacy goal, some clinical benefits were observed in patients with confirmed mBAP1 mutations, suggesting the need for further research.
Article Synopsis
- - Only a small percentage (5-8%) of adults with cancer participate in clinical trials, especially among underrepresented groups, suggesting that better communication skills by oncologists could help improve these rates.
- - A study was conducted to assess the current state of clinical trial communication training in Hematology-Oncology fellowships, involving surveys and interviews with program directors (PDs). Most PDs acknowledged a lack of training on key CCT communication skills.
- - Results indicate strong interest and feasibility for implementing a communication workshop focused on clinical trials, as PDs believe such training would be beneficial and impactful for future oncologists.
Article Synopsis
- Effective mentorship is crucial for shaping the careers of trainees in classical hematology, especially with a projected decline in the workforce in this field.
- A year-long mentorship program partnered 35 hematology/oncology fellows with 34 experienced faculty mentors to foster professional development through monthly virtual meetings.
- The program showed high success, with many mentees completing scholarly projects and subsequently securing faculty positions, indicating that strong mentorship can enhance career confidence and opportunities in classical hematology.
Background: Undiagnosed Type 2 diabetes (T2D) has been associated with advanced stage cancer at diagnosis, higher mortality, and lower long-term all-cause survival. This was a RCT pilot study to examine the feasibility of a nurse-led T2D intervention for adults with newly diagnosed cancer (≤3 months), and T2D, undiagnosed or untreated with medication, conducted at an outpatient oncology clinic affiliated with a large academic institution.
Methods: Participants needed to meet the eligibility criteria including a HbA1c level between 6.
Purpose: The COVID-19 pandemic led to unprecedented challenges in medical training, and we sought to assess the specific impact of COVID-19 on hematology-oncology (HO) fellowship programs.
Methods: We conducted a cross-sectional anonymous online survey of 103 HO program directors (PDs) in conjunction with the American Society of Hematology (ASH) and ASCO. We sought to assess the specific impact of COVID-19 on HO fellowship programs' clinical, educational, and research activities, evaluate perceptions regarding PD and trainee emotional and mental health, and identify ways to support programs.
Purpose: Graduate medical and research training has drastically changed during the COVID-19 pandemic, with widespread implementation of virtual learning, redeployment from core rotations to the care of patients with COVID-19, and significant emotional and physical stressors. The specific experience of hematology-oncology (HO) fellows during the COVID-19 pandemic is not known.
Methods: We conducted a mixed-methods study using a survey of Likert-style and open-ended questions to assess the training experience and well-being of HO fellows, including both clinical and postdoctoral trainee members of the American Society of Hematology and ASCO.
Purpose: In a professional setting, the introduction of female speakers without their professional title may have an impact on the public's perception of the female speaker. We examined how professional titles were used during speakers' introductions at the ASCO Annual Meeting.
Methods: We conducted a retrospective, observational study of video-archived speaker introductions at the 2017 and 2018 ASCO Annual Meetings.
Little is known about the effects of newer oral anticoagulants on various coagulation factors. When presented with a case of intentional or suspected overdose with an abnormal coagulation profile, it is imperative to have a working diagnostic algorithm to narrow the cause to a specific drug or drug class. This may become more crucial and time sensitive when dealing with a case of acute hemorrhage.
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