Publications by authors named "Martina Bayer"
Article Synopsis
- - Diabetes, obesity, and cancer affect more than 15% of the global population, and all three are linked to issues with cellular signaling and metabolism.
- - The study uncovers a specific signaling pathway known as the Smo-Ca(2+)-Ampk axis that can rapidly change cellular metabolism and is crucial for maintaining metabolic flexibility.
- - Researchers found that certain compounds, like cyclopamine, can selectively modify hedgehog signaling, potentially offering new treatment options for managing obesity and diabetes through improved glucose uptake in tissues.
Objective: T cells and level of the cytokine interferon-γ (IFN-γ) are increased in adipose tissue in obesity. Hedgehog (Hh) signaling has been shown to potently inhibit white adipocyte differentiation. In light of recent findings in neurons that IFN-γ and Hh signaling cross-talk, we examined their potential interaction in the context of adipogenesis.
View Article and Find Full Text PDFOver 1 billion people are estimated to be overweight, placing them at risk for diabetes, cardiovascular disease, and cancer. We performed a systems-level genetic dissection of adiposity regulation using genome-wide RNAi screening in adult Drosophila. As a follow-up, the resulting approximately 500 candidate obesity genes were functionally classified using muscle-, oenocyte-, fat-body-, and neuronal-specific knockdown in vivo and revealed hedgehog signaling as the top-scoring fat-body-specific pathway.
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