[Alveolar hemorrhage secondary to generalized systemic lupus erithematosus treated with recombinant activated factor VII. Case report and literature review].

Alveolar hemorrhage is a severe complication of systemic lupus erithematosus (SLe) associated with high mortality. Treatment includes administration of steroids and cyclophosphamide. Additionally, some reports have recommended the use of plasmapheresis, azathioprine and methotrexate.

[Recombinant factor VII activated in non-hemophiliac patients with acute severe hemorrhage in the intensive care unit].

Background: Severe hemorrhage is a frequent complication with multiple etiologies and high morbi-mortality observed among critically ill patients. Recombinant Factor VIla (rFVlla) constitutes a new therapeutic alternative.

Objective: Analyze the evolution in a non-hemophiliac patient group with severe hemorrhage treated with rFVlla.

[Toxic epidermal necrolysis].

Toxic epidermal necrolysis is the prototype of a proapoptotic disease characterized by system CD95 dysrregulation. Drugs constitute the main antigenic triggers. Hystopatologically it is characterized by epidermis detachment and necrosis with apoptotic keratinocytes.

[Myocardial depression in the burn patient].

Myocardial depression and heart failure are frequent complications in critically ill burn patients. The physiopathology is complex and involves the activation of inflammatory pathways, ischemia-reperfusion, oxidative stress and endothelial lesion. Diagnosis should be made early by means of hemodynamic monitoring.