Diagnostic Potential of Exosomal microRNAs in Colorectal Cancer.

Background: Despite the significance of colonoscopy for early diagnosis of colorectal adenocarcinoma (CRC), population-wide screening remains challenging, mainly because of low acceptance rates. Herein, exosomal (exo-miR) and free circulating microRNA (c-miR) may be used as liquid biopsies in CRC to identify individuals at risk. Direct comparison of both compartments has shown inconclusive results, which is why we directly compared a panel of 10 microRNAs in this entity.

Decrease of tibial tuberosity trochlear groove distance following mechanically aligned total knee arthroplasty.

Purpose: Anterior knee pain (AKP) is common following total knee arthroplasty. The tibial tuberosity trochlear groove distance (TTTG) influences patellofemoral joint loading in the native knee. Increased TTTG may lead to maltracking of the patella and anterior knee pain.

The interphalangeal angle as a novel radiological measurement tool for Morton's neuroma - a matched case-control study.

Background: The aim of this retrospective study was to examine if a correlation between Morton's Neuroma (MN) and an increased interphalangeal angle (IPA) or intermetatarsal angle (IMA) can be found in preoperative weightbearing dorsal-plantar X-rays of the foot.

Methods: Forty-five patients with forty-nine MN in the interspaces 2/3 or 3/4 and 49 controls were recruited for this study. Every MN was matched with an asymptomatic control without history of metatarsalgia.

Osteochondral Allograft Reconstruction of the Tibia Plateau for Posttraumatic Defects-A Novel Computer-Assisted Method Using 3D Preoperative Planning and Patient-Specific Instrumentation.

 Surgical treatment of posttraumatic defects of the knee joint is challenging. Osteochondral allograft reconstruction (OCAR) is an accepted procedure to restore the joint congruity and for pain relief, particularly in the younger population. Preoperative three-dimensional (3D) planning and patient-specific instrumentation (PSI) are well accepted for the treatment of posttraumatic deformities for several pathologies.

Improved sensitivity for detection of breast cancer by combination of miR-34a and tumor markers CA 15-3 or CEA.

Background: MicroRNAs biomarkers have shown value for diagnosis and prognosis of various cancers. Combination with established tumor markers has rarely been done.

Results: Breast cancer patients had significantly higher serum RNA loads (AUC 0.