Publications by authors named "Martin Wilms"

Article Synopsis
  • Children at familial high risk of schizophrenia (FHR-SZ) or bipolar disorder (FHR-BD) experience more physical health issues and have a higher prevalence of somatic complaints compared to the general population.
  • A study involving blood tests and interviews showed that FHR-SZ children had elevated levels of inflammatory markers like leucocytes and neutrophilocytes, alongside reporting more somatic complaints than population-based controls.
  • The findings suggest that children at FHR-SZ and FHR-BD may face additional health challenges that could influence their mental health later on, indicating a need for further research into these relationships.
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Background: Children of parents with severe mental illness report bullying more often compared with controls. We hypothesized that deviations in attributional styles may explain the increased prevalence of bullying experiences. We aimed to assess real-time responses to standardized ambiguous social situations, bullying experiences by children, their primary caregivers, and teachers, and to investigate potential associations between attributional styles and bullying.

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Background: The home environment has a major impact on child development. Parental severe mental illness can pose a challenge to the home environment of a child. We aimed to examine the home environment of children of parents with schizophrenia or bipolar disorder and controls longitudinally through at-home assessments.

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Background: Exposure to adversities in early childhood is associated with psychotic experiences and disorders in adulthood. We aimed to examine whether early childhood adversities are associated with middle childhood psychotic experiences in a cohort of children at familial high risk of schizophrenia (FHR-SZ), bipolar disorder (FHR-BP) and population-based controls (controls).

Methods: Four hundred and forty-six children from The Danish High Risk and Resilience Study - VIA7 and VIA11 participated in this study (FHR-SZ = 170; FHR-BP = 103; controls = 173).

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Background: Motor abnormalities have clinical relevance as a component of psychotic illness; they are not only a proxy of altered neurodevelopment, but also intimately related to psychotic risk. We aimed to assess motor development and its association with psychotic experiences in children with familial high risk (FHR) of schizophrenia or bipolar disorder compared with controls.

Methods: The Danish High Risk and Resilience Study is a prospective longitudinal cohort study, for which participants were extracted from Danish registers.

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Objective: Psychotic experiences are common in children and adolescents and are associated with concurrent and subsequent psychopathology. Most findings originate from general population studies, whereas little is known of the clinical outcomes of psychotic experiences in children and adolescents at familial high risk of psychosis. We examined the prevalence of psychotic experiences in middle childhood and whether early childhood psychotic experiences and developmental pathways of psychotic experiences predicted mental disorders in middle childhood in children at familial high risk of schizophrenia (FHR-SZ), bipolar disorder (FHR-BP), and a population-based control group.

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Background: The jumping to conclusions (JTC) bias, ie, making decisions based on inadequate evidence, is associated with psychosis in adults and is believed to underlie the formation of delusions. Knowledge on the early manifestations of JTC and its associations with psychotic experiences (PE) in children and adolescents is lacking.

Design: Preadolescent children (mean age 11.

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Article Synopsis
  • Research shows that children of parents with severe mental illness, like schizophrenia and bipolar disorder, are at a higher risk for developing mental health issues and negative life outcomes.
  • The Danish High-Risk and Resilience Study, which began in 2012, follows 522 children (with varying parental mental health backgrounds) through comprehensive assessments at ages 7, 11, and now 15, focusing on numerous factors affecting their development.
  • The study utilizes various methods, including brain scans and assessments of psychological and social factors, to analyze how these children are affected by their home environments and parental mental health.
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Objectives: Childhood trauma increases the risk of developing mental illness as does being born to parents with schizophrenia or bipolar disorder. We aimed to compare prevalence of lifetime childhood trauma among 11-year-old children at familial high risk of schizophrenia (FHR-SZ) or bipolar disorder (FHR-BP) compared with population-based controls (PBCs).

Design: The study is a longitudinal, prospective cohort study of children at FHR-SZ, FHR-BP, and PBCs.

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Objective: People with schizophrenia and bipolar disorder are at increased risk of having comorbid somatic illness. This is partly due to lack of physical activity, which may originate from childhood. Sleep disturbances are associated with schizophrenia and bipolar disorder.

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Background: Children at familial high-risk of schizophrenia and bipolar disorder have an elevated prevalence of mental disorders but studies of children within a narrow age range are lacking and there are few conjoint studies of these two groups. Knowledge on their mental health is important for prevention and early intervention.

Methods: The authors examined mental disorders and global functioning in children at familial high-risk of schizophrenia (FHR-SZ) and bipolar disorder (FHR-BP) compared with population-based controls.

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