Effect of Hydrogen Peroxide on the Surface and Attractiveness of Various Zirconia Implant Materials on Human Osteoblasts: An In Vitro Study.

The aim of this in vitro study was to investigate the effect of hydrogen peroxide (HO) on the surface properties of various zirconia-based dental implant materials and the response of human alveolar bone osteoblasts. For this purpose, discs of two zirconia-based materials with smooth and roughened surfaces were immersed in 20% HO for two hours. Scanning electron and atomic force microscopy showed no topographic changes after HO-treatment.

Differential osteopontin expression in human osteoblasts derived from iliac crest and alveolar bone and its role in early stages of angiogenesis.

In our previous study, we revealed significant differences of osteopontin (OPN) gene expression in primary human osteoblasts (HOBs) derived from iliac crest bone (iHOBs) and alveolar bone (aHOBs). The present study aims at assigning this discriminative expression to a possible biologic function. OPN is known to be involved in several pathologic and physiologic processes, among others angiogenesis.

Biomechanical strain-induced modulation of proliferation coincides with an ERK1/2-independent nuclear YAP localization.

Biomechanical strain induces activation of the transcriptional co-activator yes-associated protein (YAP) by nuclear re-distribution. Recent findings indicate that the mechanically responsive mitogen-activated protein kinase (MAPK) extracellular signal-regulated kinase (ERK) 1/2 is involved in the amount of nuclear YAP, reflecting its activation. In this context, we conducted experiments to detect how biomechanical strain acts on the subcellular localization of YAP in periodontal cells.

Pilot investigation of the molecular discrimination of human osteoblasts from different bone entities.

In oral and maxillofacial surgery, autologous grafts from the iliac crest remain the 'gold standard' for alveolar ridge reconstruction, whereas intraoral bone grafts are considered in smaller defects. To date, a comparison of the osteogenic potential of osteoblasts with regard to their tissue origin is missing. Primary osteoblasts have proven useful for the investigation of the tissue-specific osteogenic properties.

Influence of ultraviolet photofunctionalization on the surface characteristics of zirconia-based dental implant materials.

Objectives: To examine the effect of ultraviolet light (UV) treatment on the surface characteristics of two acid-etched zirconia-based dental implant materials.

Methods: Discs of two zirconia-based materials (Zr1 and Zr2) with smooth (m) and roughened (r) surfaces were treated by UV light for 15min. The surface topography was investigated by scanning electron microscopy (SEM) and atomic force microscopy (AFM).

Comparison of four different allogeneic bone grafts for alveolar ridge reconstruction: a preliminary histologic and biochemical analysis.

Objectives: Allograft material for alveolar ridge reconstruction is quite promising and appears to be as equally successful as bone autograft material. The aim of the present study was to compare four different allogeneic bone grafts in terms of their histologic structure and DNA content before grafting.

Study Design: Four allograft specimens from different suppliers were analyzed histologically, and the DNA content was analyzed before clinical use of the allografts.