Publications by authors named "Martin Thomasen"
Article Synopsis
- Studies show that up to 50% of variation in complex traits among genetically identical individuals is unexplained by genetics or environment.
- Researchers discovered that a protein called neuronatin (NNAT) helps protect against this unexplained variation, as seen in mice with NNAT deficiencies that exhibit abnormal growth patterns.
- In humans, a pattern of unexplained variation closely resembles the findings in mice and is linked to changes in body composition and metabolic states, particularly concerning obesity and insulin response.
Background And Aims: Bile acid malabsorption (BAM) is a debilitating disease characterized by loose stools and high stool frequency. The pathophysiology of BAM is not well-understood. We investigated postprandial enterohepatic and gluco-metabolic physiology, as well as gut microbiome composition and fecal bile acid content in patients with BAM.
View Article and Find Full Text PDFAims/hypothesis: Metabolic effects of intermittent unhealthy lifestyle in young adults are poorly studied. We investigated the gluco-metabolic and hepatic effects of participation in Roskilde Festival (1 week of binge drinking and junk food consumption) in young, healthy males.
Methods: Fourteen festival participants (FP) were studied before, during and after 1 week's participation in Roskilde Festival.
Aims/hypothesis: Individuals who had a low birthweight (LBW) are at an increased risk of insulin resistance and type 2 diabetes when exposed to high-fat overfeeding (HFO). We studied genome-wide mRNA expression and DNA methylation in subcutaneous adipose tissue (SAT) after 5 days of HFO and after a control diet in 40 young men, of whom 16 had LBW.
Methods: mRNA expression was analysed using Affymetrix Human Gene 1.