Design of the HEM-POWR study: a prospective, observational study of real-world treatment with damoctocog alfa pegol in patients with haemophilia A.

Introduction: Haemophilia A is a rare bleeding disorder caused by defects in coagulation factor VIII (FVIII). Damoctocog alfa pegol (BAY 94-9027, Jivi, Bayer, Germany) is a site-specifically PEGylated, extended-half-life, recombinant FVIII, approved for use in previously treated patients (PTPs) aged ≥12 years with haemophilia A. However, a real-world evidence regarding routine clinical use of damoctocog alfa pegol is limited.

Adherence to prophylaxis in adult patients with severe haemophilia A.

Introduction: Adherence is a cornerstone of factor VIII prophylactic treatment. Information regarding the factors with potential influence on adherence is limited, particularly in adult patients.

Aim: To assess adherence in adult patients with severe haemophilia A receiving prophylactic treatment in a real-life setting, and investigate the factors influencing adherence.

[Urinary de-diversion after diversion with chronic bladder contamination. An experimental study in male rats].

We have carried out an experimental model of urinary diversion and dis-diversion on male Wistar rats in order to study the complications that are produced after diversion, as well as to see whether the alterations continue unchanged, or increase, or diminish after dis-diversion. The following experimental design was used: a control group made up of 48 animals an a problem group of 200 animals all submitted to vesicosigmoidostomy of which 100 were designed to be subsequently dis-diverted. The sacrificed animals (n = 112) were studied for somatic, biochemical and histological parameters.

[Methods of assessing postoperative pain in children].

A study of the evaluation of postoperative pain in 210 children using physiological, reference and observation methods. A comparison with other methods leads to the conclusion that observation is the best choice and that some children do not need analgesics during the postoperative period.

[Consequences of the communication between lower urodigestive organs on gonads and gonad ducts].

Though there are not many cases described in the literature and very few for children, the existence of lower urodigestive communications may give rise to inflammatory processes in gonads and gonaducts in the male. We have carried out an experimental study of this aspect on 248 male Wistar rats according to the following design: A 48 animal control group (C) is divided into four equal subgroups sacrificed at the ages of one, two, three and four months. The problem group (P) of 200 animals are all submitted to vesicosigmoidostomy and then 100 are sacrificed after one and two months, and the other 100 are dis-diverted one and two months after the original diversion and sacrificed one month later.