Esophageal adenocarcinoma in a 40-year-old man with cystic fibrosis: coincidence or not?

Objective: To report a case of esophageal cancer in an adult patient with cystic fibrosis (CF) and review the relationship between these 2 diseases.

Case Report: A 40-year-old man with CF presented with worsening epigastric pain, weight loss, and upper gastrointestinal (GI) bleeding. Endoscopy revealed innumerable masses in the distal esophagus.